Inhibition of Intracellular Triglyceride Lipolysis Suppresses Cold-Induced Brown Adipose Tissue Metabolism and Increases Shivering in Humans. 2017

Denis P Blondin, and Frédérique Frisch, and Serge Phoenix, and Brigitte Guérin, and Éric E Turcotte, and François Haman, and Denis Richard, and André C Carpentier
Department of Medicine, Centre de Recherche du Centre Hospitalier Universitaire de Sherbrooke, Université de Sherbrooke, Sherbrooke, QC J1K 2R1, Canada.

Indirect evidence from human studies suggests that brown adipose tissue (BAT) thermogenesis is fueled predominantly by fatty acids hydrolyzed from intracellular triglycerides (TGs). However, no direct experimental evidence to support this assumption currently exists in humans. The aim of this study was to determine the role of intracellular TG in BAT thermogenesis, in cold-exposed men. Using positron emission tomography with 11C-acetate and 18F-fluorodeoxyglucose, we showed that oral nicotinic acid (NiAc) administration, an inhibitor of intracellular TG lipolysis, suppressed the cold-induced increase in BAT oxidative metabolism and glucose uptake, despite no difference in BAT blood flow. There was a commensurate increase in shivering intensity and shift toward a greater reliance on glycolytic muscle fibers without modifying total heat production. Together, these findings show that intracellular TG lipolysis is critical for BAT thermogenesis and provides experimental evidence for a reciprocal role of BAT thermogenesis and shivering in cold-induced thermogenesis in humans.

UI MeSH Term Description Entries
D007700 Kinetics The rate dynamics in chemical or physical systems.
D008066 Lipolysis The metabolic process of breaking down LIPIDS to release FREE FATTY ACIDS, the major oxidative fuel for the body. Lipolysis may involve dietary lipids in the DIGESTIVE TRACT, circulating lipids in the BLOOD, and stored lipids in the ADIPOSE TISSUE or the LIVER. A number of enzymes are involved in such lipid hydrolysis, such as LIPASE and LIPOPROTEIN LIPASE from various tissues. Lipolyses
D008297 Male Males
D009525 Niacin A water-soluble vitamin of the B complex occurring in various animal and plant tissues. It is required by the body for the formation of coenzymes NAD and NADP. It has PELLAGRA-curative, vasodilating, and antilipemic properties. Nicotinic Acid,3-Pyridinecarboxylic Acid,Enduracin,Induracin,Lithium Nicotinate,Niacin Aluminum Salt,Niacin Ammonium Salt,Niacin Calcium Salt,Niacin Cobalt (2+) Salt,Niacin Copper (2+) Salt,Niacin Hydrochloride,Niacin Iron (2+) Salt,Niacin Lithium Salt,Niacin Lithium Salt, Hemihydrate,Niacin Magnesium Salt,Niacin Manganese (2+) Salt,Niacin Potassium Salt,Niacin Sodium Salt,Niacin Tartrate,Niacin Tosylate,Niacin Zinc Salt,Nicamin,Nico-400,Nicobid,Nicocap,Nicolar,Nicotinate,Wampocap,3 Pyridinecarboxylic Acid,Aluminum Salt, Niacin,Hydrochloride, Niacin,Nico 400,Nico400,Nicotinate, Lithium,Potassium Salt, Niacin,Sodium Salt, Niacin,Tartrate, Niacin,Tosylate, Niacin
D009928 Organ Specificity Characteristic restricted to a particular organ of the body, such as a cell type, metabolic response or expression of a particular protein or antigen. Tissue Specificity,Organ Specificities,Specificities, Organ,Specificities, Tissue,Specificity, Organ,Specificity, Tissue,Tissue Specificities
D010084 Oxidation-Reduction A chemical reaction in which an electron is transferred from one molecule to another. The electron-donating molecule is the reducing agent or reductant; the electron-accepting molecule is the oxidizing agent or oxidant. Reducing and oxidizing agents function as conjugate reductant-oxidant pairs or redox pairs (Lehninger, Principles of Biochemistry, 1982, p471). Redox,Oxidation Reduction
D012039 Regional Blood Flow The flow of BLOOD through or around an organ or region of the body. Blood Flow, Regional,Blood Flows, Regional,Flow, Regional Blood,Flows, Regional Blood,Regional Blood Flows
D002001 Adipose Tissue, Brown A thermogenic form of adipose tissue composed of BROWN ADIPOCYTES. It is found in newborns of many species including humans, and in hibernating mammals. Brown fat is richly vascularized, innervated, and densely packed with MITOCHONDRIA which can generate heat directly from the stored lipids. Brown Fat,Hibernating Gland,Brown Adipose Tissue,Fat, Brown,Tissue, Brown Adipose
D002250 Carbon Radioisotopes Unstable isotopes of carbon that decay or disintegrate emitting radiation. C atoms with atomic weights 10, 11, and 14-16 are radioactive carbon isotopes. Radioisotopes, Carbon
D003080 Cold Temperature An absence of warmth or heat or a temperature notably below an accustomed norm. Cold,Cold Temperatures,Temperature, Cold,Temperatures, Cold

Related Publications

Denis P Blondin, and Frédérique Frisch, and Serge Phoenix, and Brigitte Guérin, and Éric E Turcotte, and François Haman, and Denis Richard, and André C Carpentier
October 2013, Nature reviews. Endocrinology,
Denis P Blondin, and Frédérique Frisch, and Serge Phoenix, and Brigitte Guérin, and Éric E Turcotte, and François Haman, and Denis Richard, and André C Carpentier
December 1977, Journal of applied physiology: respiratory, environmental and exercise physiology,
Denis P Blondin, and Frédérique Frisch, and Serge Phoenix, and Brigitte Guérin, and Éric E Turcotte, and François Haman, and Denis Richard, and André C Carpentier
January 2018, Frontiers in endocrinology,
Denis P Blondin, and Frédérique Frisch, and Serge Phoenix, and Brigitte Guérin, and Éric E Turcotte, and François Haman, and Denis Richard, and André C Carpentier
September 2005, American journal of physiology. Endocrinology and metabolism,
Denis P Blondin, and Frédérique Frisch, and Serge Phoenix, and Brigitte Guérin, and Éric E Turcotte, and François Haman, and Denis Richard, and André C Carpentier
April 2023, Endocrinology and metabolism (Seoul, Korea),
Denis P Blondin, and Frédérique Frisch, and Serge Phoenix, and Brigitte Guérin, and Éric E Turcotte, and François Haman, and Denis Richard, and André C Carpentier
January 1976, Biochimie,
Denis P Blondin, and Frédérique Frisch, and Serge Phoenix, and Brigitte Guérin, and Éric E Turcotte, and François Haman, and Denis Richard, and André C Carpentier
July 2007, American journal of physiology. Gastrointestinal and liver physiology,
Denis P Blondin, and Frédérique Frisch, and Serge Phoenix, and Brigitte Guérin, and Éric E Turcotte, and François Haman, and Denis Richard, and André C Carpentier
September 1994, [Hokkaido igaku zasshi] The Hokkaido journal of medical science,
Denis P Blondin, and Frédérique Frisch, and Serge Phoenix, and Brigitte Guérin, and Éric E Turcotte, and François Haman, and Denis Richard, and André C Carpentier
March 2014, The Journal of clinical endocrinology and metabolism,
Denis P Blondin, and Frédérique Frisch, and Serge Phoenix, and Brigitte Guérin, and Éric E Turcotte, and François Haman, and Denis Richard, and André C Carpentier
November 2017, Cell metabolism,
Copied contents to your clipboard!