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Intrathecal delivery methods have been used for many decades to treat a broad range of central nervous system disorders. A literature review demonstrated that intracerebroventricular route is an established and well-tolerated method for prolonged central nervous system drug delivery in pediatric and adult populations. Intracerebroventricular devices were present in patients from one to 7156 days. The number of punctures per device ranged from 2 to 280. Noninfectious complication rates per patient (range, 1.0% to 33.0%) were similar to infectious complication rates (0.0% to 27.0%). Clinician experience and training and the use of strict aseptic techniques have been shown to reduce the frequency of complications.
Jessica L Cohen-Pfeffer, and
Sridharan Gururangan, and
Thomas Lester, and
Daniel A Lim, and
Adam J Shaywitz, and
Manfred Westphal, and
Irene Slavc
September 2017,
Translational and clinical pharmacology,
Jessica L Cohen-Pfeffer, and
Sridharan Gururangan, and
Thomas Lester, and
Daniel A Lim, and
Adam J Shaywitz, and
Manfred Westphal, and
Irene Slavc
December 1981,
Journal of pharmaceutical sciences,
Jessica L Cohen-Pfeffer, and
Sridharan Gururangan, and
Thomas Lester, and
Daniel A Lim, and
Adam J Shaywitz, and
Manfred Westphal, and
Irene Slavc
November 1985,
Pharmacology, biochemistry, and behavior,
Jessica L Cohen-Pfeffer, and
Sridharan Gururangan, and
Thomas Lester, and
Daniel A Lim, and
Adam J Shaywitz, and
Manfred Westphal, and
Irene Slavc
February 2016,
Clinical pharmacokinetics,
Jessica L Cohen-Pfeffer, and
Sridharan Gururangan, and
Thomas Lester, and
Daniel A Lim, and
Adam J Shaywitz, and
Manfred Westphal, and
Irene Slavc
June 1993,
Pharmaceutical research,
Jessica L Cohen-Pfeffer, and
Sridharan Gururangan, and
Thomas Lester, and
Daniel A Lim, and
Adam J Shaywitz, and
Manfred Westphal, and
Irene Slavc
March 2005,
Journal of controlled release : official journal of the Controlled Release Society,
Jessica L Cohen-Pfeffer, and
Sridharan Gururangan, and
Thomas Lester, and
Daniel A Lim, and
Adam J Shaywitz, and
Manfred Westphal, and
Irene Slavc
April 2013,
International urogynecology journal,
Jessica L Cohen-Pfeffer, and
Sridharan Gururangan, and
Thomas Lester, and
Daniel A Lim, and
Adam J Shaywitz, and
Manfred Westphal, and
Irene Slavc
October 2018,
Brain research bulletin,
Jessica L Cohen-Pfeffer, and
Sridharan Gururangan, and
Thomas Lester, and
Daniel A Lim, and
Adam J Shaywitz, and
Manfred Westphal, and
Irene Slavc
May 2024,
Drug discovery today,
Jessica L Cohen-Pfeffer, and
Sridharan Gururangan, and
Thomas Lester, and
Daniel A Lim, and
Adam J Shaywitz, and
Manfred Westphal, and
Irene Slavc
January 2024,
Frontiers in chemistry,
