BIOMAT Database Logo BIOMAT Database Logo

Comparative Study of Antitumor Efficiency of Intraperitoneal and Intravenous Cytostatics in Experimental Rats with Disseminated Ovarian Cancer. 2017

V G Bespalov, and E A Vyshinskaya, and I N Vasil'eva, and A L Semenov, and M A Maidin, and N V Barakova, and A N Stukov
Research Laboratory of Cancer Chemoprophylaxis and Oncopharmacology, I. N. Petrov Research Institute of Oncology, Ministry of Health of the Russian Federation, St. Petersburg, Russia.

Antitumor efficiencies of cytostatics dioxadet, cisplatin, mitomycin C, melphalan, and paclitaxel after a single intraperitoneal or intravenous injection in doses of 1.5, 4, 1.5, 2, and 5 mg/kg, respectively, were studied on the model of transplanted ovarian tumor in 124 rats. The antitumor effects were evaluated by the increase in median survival. Dioxadet, cisplatin, and melphalan injected intraperitoneally significantly prolonged the lifespan median - by 79, 88, and 114%, respectively, and were in fact ineffective, when injected intravenously. Intraperitoneal mitomycin C prolonged lifespan median by just 35%, intravenous - by 152%. Paclitaxel injected intraperitoneally and intravenously prolonged the lifespan median by 45 and 81%, respectively.

UI MeSH Term Description Entries
D007274 Injections, Intraperitoneal Forceful administration into the peritoneal cavity of liquid medication, nutrient, or other fluid through a hollow needle piercing the abdominal wall. Intraperitoneal Injections,Injection, Intraperitoneal,Intraperitoneal Injection
D007275 Injections, Intravenous Injections made into a vein for therapeutic or experimental purposes. Intravenous Injections,Injection, Intravenous,Intravenous Injection
D008558 Melphalan An alkylating nitrogen mustard that is used as an antineoplastic in the form of the levo isomer - MELPHALAN, the racemic mixture - MERPHALAN, and the dextro isomer - MEDPHALAN; toxic to bone marrow, but little vesicant action; potential carcinogen. Medphalan,Merphalan,Phenylalanine Mustard,Sarcolysine,Sarkolysin,4-(Bis(2-chloroethyl)amino)phenylalanine,Alkeran,L-PAM,Mustard, Phenylalanine
D009368 Neoplasm Transplantation Experimental transplantation of neoplasms in laboratory animals for research purposes. Transplantation, Neoplasm,Neoplasm Transplantations,Transplantations, Neoplasm
D010051 Ovarian Neoplasms Tumors or cancer of the OVARY. These neoplasms can be benign or malignant. They are classified according to the tissue of origin, such as the surface EPITHELIUM, the stromal endocrine cells, and the totipotent GERM CELLS. Cancer of Ovary,Ovarian Cancer,Cancer of the Ovary,Neoplasms, Ovarian,Ovary Cancer,Ovary Neoplasms,Cancer, Ovarian,Cancer, Ovary,Cancers, Ovarian,Cancers, Ovary,Neoplasm, Ovarian,Neoplasm, Ovary,Neoplasms, Ovary,Ovarian Cancers,Ovarian Neoplasm,Ovary Cancers,Ovary Neoplasm
D002945 Cisplatin An inorganic and water-soluble platinum complex. After undergoing hydrolysis, it reacts with DNA to produce both intra and interstrand crosslinks. These crosslinks appear to impair replication and transcription of DNA. The cytotoxicity of cisplatin correlates with cellular arrest in the G2 phase of the cell cycle. Platinum Diamminodichloride,cis-Diamminedichloroplatinum(II),cis-Dichlorodiammineplatinum(II),Biocisplatinum,Dichlorodiammineplatinum,NSC-119875,Platidiam,Platino,Platinol,cis-Diamminedichloroplatinum,cis-Platinum,Diamminodichloride, Platinum,cis Diamminedichloroplatinum,cis Platinum
D005260 Female Females
D000231 Adenocarcinoma, Papillary An adenocarcinoma containing finger-like processes of vascular connective tissue covered by neoplastic epithelium, projecting into cysts or the cavity of glands or follicles. It occurs most frequently in the ovary and thyroid gland. (Stedman, 25th ed) Adenocarcinomas, Papillary,Papillary Adenocarcinoma,Papillary Adenocarcinomas
D000818 Animals Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA. Animal,Metazoa,Animalia
D000970 Antineoplastic Agents Substances that inhibit or prevent the proliferation of NEOPLASMS. Anticancer Agent,Antineoplastic,Antineoplastic Agent,Antineoplastic Drug,Antitumor Agent,Antitumor Drug,Cancer Chemotherapy Agent,Cancer Chemotherapy Drug,Anticancer Agents,Antineoplastic Drugs,Antineoplastics,Antitumor Agents,Antitumor Drugs,Cancer Chemotherapy Agents,Cancer Chemotherapy Drugs,Chemotherapeutic Anticancer Agents,Chemotherapeutic Anticancer Drug,Agent, Anticancer,Agent, Antineoplastic,Agent, Antitumor,Agent, Cancer Chemotherapy,Agents, Anticancer,Agents, Antineoplastic,Agents, Antitumor,Agents, Cancer Chemotherapy,Agents, Chemotherapeutic Anticancer,Chemotherapy Agent, Cancer,Chemotherapy Agents, Cancer,Chemotherapy Drug, Cancer,Chemotherapy Drugs, Cancer,Drug, Antineoplastic,Drug, Antitumor,Drug, Cancer Chemotherapy,Drug, Chemotherapeutic Anticancer,Drugs, Antineoplastic,Drugs, Antitumor,Drugs, Cancer Chemotherapy

Related Publications

V G Bespalov, and E A Vyshinskaya, and I N Vasil'eva, and A L Semenov, and M A Maidin, and N V Barakova, and A N Stukov
Comparative efficiency of intraperitoneal interleukine-2 and interferon-A in rats with experimental endometriosis.
March 2007, Bulletin of experimental biology and medicine,
V G Bespalov, and E A Vyshinskaya, and I N Vasil'eva, and A L Semenov, and M A Maidin, and N V Barakova, and A N Stukov
[Antitumor effect of dioxadet in intraperitoneal chemoperfusion treatment for advanced ovarian cancer in experimental setting].
January 2014, Voprosy onkologii,
V G Bespalov, and E A Vyshinskaya, and I N Vasil'eva, and A L Semenov, and M A Maidin, and N V Barakova, and A N Stukov
A comparative study of intraperitoneal carboplatin versus intravenous carboplatin with intravenous cyclophosphamide in both arms as initial chemotherapy for stage III ovarian cancer.
January 1999, Oncology,
V G Bespalov, and E A Vyshinskaya, and I N Vasil'eva, and A L Semenov, and M A Maidin, and N V Barakova, and A N Stukov
Phase I study of intravenous oxaliplatin and intraperitoneal docetaxel in recurrent ovarian cancer.
January 2019, International journal of gynecological cancer : official journal of the International Gynecological Cancer Society,
V G Bespalov, and E A Vyshinskaya, and I N Vasil'eva, and A L Semenov, and M A Maidin, and N V Barakova, and A N Stukov
[Therapy of ovarian cancer with cytostatics].
January 1965, Archiv fur Gynakologie,
V G Bespalov, and E A Vyshinskaya, and I N Vasil'eva, and A L Semenov, and M A Maidin, and N V Barakova, and A N Stukov
Intraperitoneal cytostatics impair healing of experimental intestinal anastomoses.
June 1991, British journal of cancer,
V G Bespalov, and E A Vyshinskaya, and I N Vasil'eva, and A L Semenov, and M A Maidin, and N V Barakova, and A N Stukov
Intraperitoneal chemotherapy in ovarian cancer remains experimental.
October 2006, Journal of clinical oncology : official journal of the American Society of Clinical Oncology,
V G Bespalov, and E A Vyshinskaya, and I N Vasil'eva, and A L Semenov, and M A Maidin, and N V Barakova, and A N Stukov
COMBINED TREATMENT OF DISSEMINATED OVARIAN CARCINOMA WITH COBALT TELETHERAPY AND CYTOSTATICS (CHLORAMBUCIL).
July 1964, American journal of obstetrics and gynecology,
V G Bespalov, and E A Vyshinskaya, and I N Vasil'eva, and A L Semenov, and M A Maidin, and N V Barakova, and A N Stukov
Carrier-free multifunctional nanomedicine for intraperitoneal disseminated ovarian cancer therapy.
February 2022, Journal of nanobiotechnology,
V G Bespalov, and E A Vyshinskaya, and I N Vasil'eva, and A L Semenov, and M A Maidin, and N V Barakova, and A N Stukov
Intraperitoneal hyperthermic perfusion chemotherapy of patients with chemotherapy-resistant peritoneal disseminated ovarian cancer.
January 2001, International journal of gynecological cancer : official journal of the International Gynecological Cancer Society,
Copied contents to your clipboard!