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The peritoneal surface of the lesion was observed after treatment by scanning electron microscopy (SEM) to evaluate the anticancer effect of Cisplatinum (CDDP). CDDP (0.1 mg/day bolus) was injected intraperitoneally to the DDN mice in which 3 X 10(7) MM2 tumor cells were inoculated the day before treatment. The anticancer effect was examined from 2nd to 7th consecutive day after tumor cells implantation, and the following results were obtained. 1) MM2 tumor cells were covered by powder-like material consisted with CDDP and were destroyed. 2) Mesothelial cells were also degenerated by powder-like material of CDDP. 3) In CDDP group, only a little intraperitoneal effusion and adhesion were observed. 4) These results suggested that CDDP exerted anti-tumor cell effects on peritonitis carcinomatosa.
T Kurokawa, and
S Tamakuma, and
Y Ohsaki
January 1989,
Operative dentistry,
T Kurokawa, and
S Tamakuma, and
Y Ohsaki
January 1985,
Acta oto-laryngologica. Supplementum,
T Kurokawa, and
S Tamakuma, and
Y Ohsaki
January 1987,
Journal of electron microscopy,
T Kurokawa, and
S Tamakuma, and
Y Ohsaki
April 1989,
Ou Daigaku shigakushi,
T Kurokawa, and
S Tamakuma, and
Y Ohsaki
January 1992,
Zhongguo ji sheng chong xue yu ji sheng chong bing za zhi = Chinese journal of parasitology & parasitic diseases,
T Kurokawa, and
S Tamakuma, and
Y Ohsaki
January 1982,
Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie,
T Kurokawa, and
S Tamakuma, and
Y Ohsaki
August 2001,
Kaibogaku zasshi. Journal of anatomy,
T Kurokawa, and
S Tamakuma, and
Y Ohsaki
January 1996,
Eye (London, England),
T Kurokawa, and
S Tamakuma, and
Y Ohsaki
November 1977,
Acta pathologica japonica,
T Kurokawa, and
S Tamakuma, and
Y Ohsaki
January 1986,
Scanning electron microscopy,
