-transparent.png){kind=logo}
One hundred ninety-six patients with acute myelogenous leukemia (AML) were treated with intensive induction chemotherapy using similar daunorubicin/cytarabine/thioguanine regimens. Treatment results of 44 patients who had a documented preleukemic syndrome or cytopenia present for more than 2 months before developing over AML were compared with 152 patients with de novo AML. Eighteen (41%) patients with preleukemia evolving into AML achieved complete remission compared with 111 (73%) patients with de novo AML (P less than .01). Patients with preleukemia-AML had a significantly longer period to recovery of granulocytes. Multivariate analysis indicated that presence of a previous preleukemic syndrome and advancing age were independent poor prognostic indicators for achieving remission. For patients who achieved remission, disease-free survival and overall survival were also inferior for patients with previous preleukemia; disease-free survival was 17 +/- 17% at 3 years compared with 29 +/- 10% in patients with de novo AML (P = .02). These data indicate that intensive chemotherapy has limited efficacy in patients with AML following a preleukemic syndrome. Durable remissions may be achieved in some patients.
J L Gajewski, and
W G Ho, and
S D Nimer, and
K F Hirji, and
L Gekelman, and
A D Jacobs, and
R E Champlin
June 1981,
Annals of internal medicine,
J L Gajewski, and
W G Ho, and
S D Nimer, and
K F Hirji, and
L Gekelman, and
A D Jacobs, and
R E Champlin
January 1990,
Haematology and blood transfusion,
J L Gajewski, and
W G Ho, and
S D Nimer, and
K F Hirji, and
L Gekelman, and
A D Jacobs, and
R E Champlin
September 1993,
Gan to kagaku ryoho. Cancer & chemotherapy,
J L Gajewski, and
W G Ho, and
S D Nimer, and
K F Hirji, and
L Gekelman, and
A D Jacobs, and
R E Champlin
January 2001,
Advances in therapy,
J L Gajewski, and
W G Ho, and
S D Nimer, and
K F Hirji, and
L Gekelman, and
A D Jacobs, and
R E Champlin
August 2009,
Anticancer research,
J L Gajewski, and
W G Ho, and
S D Nimer, and
K F Hirji, and
L Gekelman, and
A D Jacobs, and
R E Champlin
January 1987,
Haematology and blood transfusion,
J L Gajewski, and
W G Ho, and
S D Nimer, and
K F Hirji, and
L Gekelman, and
A D Jacobs, and
R E Champlin
September 1981,
Blood,
J L Gajewski, and
W G Ho, and
S D Nimer, and
K F Hirji, and
L Gekelman, and
A D Jacobs, and
R E Champlin
January 2005,
Current hematology reports,
J L Gajewski, and
W G Ho, and
S D Nimer, and
K F Hirji, and
L Gekelman, and
A D Jacobs, and
R E Champlin
January 1976,
The American journal of the medical sciences,
J L Gajewski, and
W G Ho, and
S D Nimer, and
K F Hirji, and
L Gekelman, and
A D Jacobs, and
R E Champlin
December 1985,
Cancer treatment reports,
