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Upper arm and cardiac magnetic resonance imaging in Duchenne muscular dystrophy. 2016

Lasya Gaur, and Alexander Hanna, and W Patricia Bandettini, and Kenneth H Fischbeck, and Andrew E Arai, and Ami Mankodi
Advanced Cardiovascular Imaging National Heart, Lung and Blood Institute Bethesda Maryland; Present address: Pediatric Cardiology The Johns Hopkins Hospital Baltimore Maryland.

We analyzed quantitative maps of T1 and T2 relaxation times and muscle fat fraction measurements in magnetic resonance imaging of the upper arm skeletal muscles and heart in ambulatory boys with Duchenne muscular dystrophy and age-range-matched healthy volunteer boys. The cardiac-optimized sequences detected fatty infiltration and edema in the upper arm skeletal muscles but not the myocardium in these Duchenne muscular dystrophy boys who had normal ejection fraction. Imaging the heart and skeletal muscle using the same magnetic resonance imaging methods during a single scan may be useful in assessing relative disease status and therapeutic response in clinical trials of Duchenne muscular dystrophy.

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