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Copper-catalyzed aromatic C-H alkoxylation with alcohols under aerobic conditions. 2017

Wenkui Lu, and Hui Xu, and Zengming Shen
School of Chemistry and Chemical Engineering, Shanghai Jiao Tong University, 800 DongchuanRoad, Shanghai 200240, China. shenzengming@sjtu.edu.cn.

An efficient protocol for copper-catalyzed aromatic C-H alkoxylation with alcohols has been developed under aerobic conditions. The protocol provides a complementary method to couple arenes and alcohols to furnish aromatic ethers. The advantages of this method are the employment of a cheap Cu(OAc)2 catalyst, oxygen as the terminal oxidant and alcohol as both an alkoxy reagent and a solvent. Notably, the catalytic amount of benzoic acid plays a significant role in this transformation.

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