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The purpose of this study was to characterize the pharmacokinetics of a subcutaneously implanted tissue-chamber model. Thermoplastic tissue chambers were implanted in the paralumbar fossae of six steers. Starting 30 days after implantation, the distribution of intravenously administered antipyrine and phenylbutazone into the tissue chambers was studied. These pharmacokinetic experiments were repeated 10 days later to determine the effect of time after implantation on tissue-chamber distribution. Fifty days after implantation, tissue chambers were drained of transudate, refilled with sterile saline and the rate of influx of endogenous urea, creatinine and albumin was measured. Delayed diffusion of antipyrine and phenylbutazone into tissue chambers was well described using a compartmental model in which tissue-chamber fluid represented the third of three compartments arranged in series. The distribution of antipyrine into tissue chambers was greater than that of phenylbutazone; an observation which is well correlated with the high degree of protein binding of phenylbutazone. There was no effect of time on the penetration of the two agents. Rapid diffusion of urea and creatinine and extremely slow influx of albumin into chambers showed that these chambers formed true interstitial compartments.
C R Clarke, and
C R Short, and
D W Bourne, and
E A Usenik
November 1975,
Journal of medical microbiology,
C R Clarke, and
C R Short, and
D W Bourne, and
E A Usenik
November 1973,
Experimental eye research,
C R Clarke, and
C R Short, and
D W Bourne, and
E A Usenik
October 1975,
Antimicrobial agents and chemotherapy,
C R Clarke, and
C R Short, and
D W Bourne, and
E A Usenik
October 1986,
American journal of veterinary research,
C R Clarke, and
C R Short, and
D W Bourne, and
E A Usenik
September 1965,
Laboratory investigation; a journal of technical methods and pathology,
C R Clarke, and
C R Short, and
D W Bourne, and
E A Usenik
December 1993,
Journal of biomedical materials research,
C R Clarke, and
C R Short, and
D W Bourne, and
E A Usenik
June 1986,
Deutsche medizinische Wochenschrift (1946),
C R Clarke, and
C R Short, and
D W Bourne, and
E A Usenik
April 1997,
The British journal of oral & maxillofacial surgery,
C R Clarke, and
C R Short, and
D W Bourne, and
E A Usenik
December 1997,
Plastic and reconstructive surgery,
C R Clarke, and
C R Short, and
D W Bourne, and
E A Usenik
January 1960,
Wilhelm Roux' Archiv fur Entwicklungsmechanik der Organismen,
