Biomaterial Database

[A clinical study on cefpodoxime proxetil dry syrup in pediatric infections]. 1989

Y Wagatsuma, and A Takase, and N Fukushima, and A Ishikawa, and S Takahashi

Department of Pediatrics, Sapporo City General Hospital.

Clinical studies on cefpodoxime proxetil (CS-807, CPDX-PR) dry syrup were carried out in the field of pediatrics, and the results are summarized as follows. 1. Eleven year-old male and 12 year-old female were administered orally at a dose level of 5.6 and 6.0 mg/kg, respectively, after or before meal. Cmax and T1/2 were 5.0 micrograms/ml and 2.13 hours, respectively, for the male and 4.04 micrograms/ml and 1.63 hours, respectively, for the female. 2. Good clinical responses were obtained in 21 of 22 child patients with bacterial pharyngitis, tonsillitis, scarlet fever and urinary tract infections. One child with Mycoplasma pneumonia did not respond. As to bacteriological effects, eradication of pathogens was observed in 8 out of 11 strains, showing an eradication rate of 72.7%. 3. As to side effect, 1 case of loose stool was observed, but there was no need of discontinuing the drug treatment.

UI	MeSH Term	Description	Entries
D007223	Infant	A child between 1 and 23 months of age.	Infants
D008297	Male		Males
D010612	Pharyngitis	Inflammation of the throat (PHARYNX).	Sore Throat,Pharyngitides,Sore Throats,Throat, Sore
D002621	Chemistry	A basic science concerned with the composition, structure, and properties of matter; and the reactions that occur between substances and the associated energy exchange.
D002648	Child	A person 6 to 12 years of age. An individual 2 to 5 years old is CHILD, PRESCHOOL.	Children
D002675	Child, Preschool	A child between the ages of 2 and 5.	Children, Preschool,Preschool Child,Preschool Children
D004341	Drug Evaluation	Any process by which toxicity, metabolism, absorption, elimination, preferred route of administration, safe dosage range, etc., for a drug or group of drugs is determined through clinical assessment in humans or veterinary animals.	Evaluation Studies, Drug,Drug Evaluation Studies,Drug Evaluation Study,Drug Evaluations,Evaluation Study, Drug,Evaluation, Drug,Evaluations, Drug,Studies, Drug Evaluation,Study, Drug Evaluation
D005260	Female		Females
D006801	Humans	Members of the species Homo sapiens.	Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D000097627	Cefpodoxime Proxetil	A prodrug of its active metabolite CEFPODOXIME.	1-(Isopropoxycarbonyloxy)ethyl-7-(2-(2-Amino-4-thiazolyl)-2-(Methoxyimino)Acetamido)-3-Methoxymethyl-8-oxo-5-thia-1-Azabicyclo(4,2,0)-oct-2-ene-2-Carboxylate,Cephalosporin 807,Orelox,Otreon,U-76252,CS 807,CS-807,U 76252,Vantin,76252, U,807, CS,807, Cephalosporin,Proxetil, Cefpodoxime,U76252