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Wall teichoic acids mediate increased virulence in Staphylococcus aureus. 2017
Stefanie Wanner, and
Jessica Schade, and
Daniela Keinhörster, and
Nicola Weller, and
Shilpa E George, and
Larissa Kull, and
Jochen Bauer, and
Timo Grau, and
Volker Winstel, and
Henriette Stoy, and
Dorothee Kretschmer, and
Julia Kolata, and
Christiane Wolz, and
Barbara M Bröker, and
Christopher Weidenmaier
Department of Medicine, Interfacultary Institute for Microbiology and Infection Medicine (IMIT), University of Tübingen, Elfriede-Aulhorn Straße 6, 72076 Tübingen, Germany.
Community-associated methicillin-resistant Staphylococcus aureus (CA-MRSA) are the cause of a severe pandemic consisting primarily of skin and soft tissue infections. The underlying pathomechanisms have not been fully understood and we report here a mechanism that plays an important role for the elevated virulence of CA-MRSA. Surprisingly, skin abscess induction in an animal model was correlated with the amount of a major cell wall component of S. aureus, termed wall teichoic acid (WTA). CA-MRSA exhibited increased cell-wall-associated WTA content (WTAhigh) and thus were more active in inducing abscess formation via a WTA-dependent and T-cell-mediated mechanism than S. aureus strains with a WTAlow phenotype. We show here that WTA is directly involved in S. aureus strain-specific virulence and provide insight into the underlying molecular mechanisms that could guide the development of novel anti-infective strategies.
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