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In order to gain experience about the detection of adverse effects during a scientific procedure, we carried out a clinical examination of rats with zinc deficiency. In weanling rats fed a zinc-deficient diet (30 mumol zinc/kg) for 10 days, the mean tibial concentration of zinc was reduced by 53% and body weight gain by 73% when compared with rats fed a diet containing an adequate amount of zinc (150 mumol zinc/kg). In a small open field on day 9 of the experiment, the deficient rats more frequently displayed the posture standing upright with elevated heels. On day 10 of the experiment a clinical examination was carried out at random and 'blind' by three independent assessors. Out of 20 variables scored quantitatively on each individual animal, only body size differed between normal and deficient rats. Other classical signs of zinc deficiency, such as alopecia, dermatitis and diarrhoea, were not detected. It is concluded that in this rat model of zinc deficiency, no evidence for extreme discomfort can be demonstrated.
H Van Herck, and
J P Van Wouwe, and
M Veldhuizen, and
V Baumans, and
F R Stafleu, and
A C Beynen
January 1986,
Acta paediatrica Scandinavica. Supplement,
H Van Herck, and
J P Van Wouwe, and
M Veldhuizen, and
V Baumans, and
F R Stafleu, and
A C Beynen
April 1950,
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H Van Herck, and
J P Van Wouwe, and
M Veldhuizen, and
V Baumans, and
F R Stafleu, and
A C Beynen
February 2003,
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H Van Herck, and
J P Van Wouwe, and
M Veldhuizen, and
V Baumans, and
F R Stafleu, and
A C Beynen
December 1950,
Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.),
H Van Herck, and
J P Van Wouwe, and
M Veldhuizen, and
V Baumans, and
F R Stafleu, and
A C Beynen
August 1982,
Journal of pharmacobio-dynamics,
H Van Herck, and
J P Van Wouwe, and
M Veldhuizen, and
V Baumans, and
F R Stafleu, and
A C Beynen
October 1986,
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H Van Herck, and
J P Van Wouwe, and
M Veldhuizen, and
V Baumans, and
F R Stafleu, and
A C Beynen
May 1969,
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H Van Herck, and
J P Van Wouwe, and
M Veldhuizen, and
V Baumans, and
F R Stafleu, and
A C Beynen
January 1983,
Acta neuropathologica,
H Van Herck, and
J P Van Wouwe, and
M Veldhuizen, and
V Baumans, and
F R Stafleu, and
A C Beynen
January 2012,
Journal of behavioral and brain science,
H Van Herck, and
J P Van Wouwe, and
M Veldhuizen, and
V Baumans, and
F R Stafleu, and
A C Beynen
April 2020,
Biological trace element research,
