Levels of CCK immunoreactivity and dopamine in the nucleus accumbens after 6-hydroxydopamine lesions of the ventral tegmental area and the nucleus accumbens. 1989

Y Igarashi, and V M Wiegant, and J M Van Ree
Rudolf Magnus Institute of Pharmacology, Medical Faculty, University of Utrecht, The Netherlands.

The effects of 6-hydroxydopamine (6-OHDA) injected into either the ventral tegmental area (VTA) or the nucleus accumbens on dopamine and its metabolite DOPAC and CCK-immunoreactivity in the nucleus accumbens were studied. Measurements were made 1, 3 and 6 weeks after the lesion in both the anterior and posterior part of the nucleus accumbens. 6-OHDA applied in the VTA reduced the level of DA and DOPAC, but did not affect the CCK content in the nucleus accumbens. 6-OHDA lesions in the anterior part of the nucleus accumbens produced depletion of DA and DOPAC from one week after the injection, and decreased the CCK content 6 weeks after the injection. The results suggest that in the nucleus accumbens DA and CCK are localized, at least for the major part, in different nerve terminals.

UI MeSH Term Description Entries
D008297 Male Males
D009714 Nucleus Accumbens Collection of pleomorphic cells in the caudal part of the anterior horn of the LATERAL VENTRICLE, in the region of the OLFACTORY TUBERCLE, lying between the head of the CAUDATE NUCLEUS and the ANTERIOR PERFORATED SUBSTANCE. It is part of the so-called VENTRAL STRIATUM, a composite structure considered part of the BASAL GANGLIA. Accumbens Nucleus,Nucleus Accumbens Septi,Accumbens Septi, Nucleus,Accumbens Septus, Nucleus,Accumbens, Nucleus,Nucleus Accumbens Septus,Nucleus, Accumbens,Septi, Nucleus Accumbens,Septus, Nucleus Accumbens
D011863 Radioimmunoassay Classic quantitative assay for detection of antigen-antibody reactions using a radioactively labeled substance (radioligand) either directly or indirectly to measure the binding of the unlabeled substance to a specific antibody or other receptor system. Non-immunogenic substances (e.g., haptens) can be measured if coupled to larger carrier proteins (e.g., bovine gamma-globulin or human serum albumin) capable of inducing antibody formation. Radioimmunoassays
D011919 Rats, Inbred Strains Genetically identical individuals developed from brother and sister matings which have been carried out for twenty or more generations or by parent x offspring matings carried out with certain restrictions. This also includes animals with a long history of closed colony breeding. August Rats,Inbred Rat Strains,Inbred Strain of Rat,Inbred Strain of Rats,Inbred Strains of Rats,Rat, Inbred Strain,August Rat,Inbred Rat Strain,Inbred Strain Rat,Inbred Strain Rats,Inbred Strains Rat,Inbred Strains Rats,Rat Inbred Strain,Rat Inbred Strains,Rat Strain, Inbred,Rat Strains, Inbred,Rat, August,Rat, Inbred Strains,Rats Inbred Strain,Rats Inbred Strains,Rats, August,Rats, Inbred Strain,Strain Rat, Inbred,Strain Rats, Inbred,Strain, Inbred Rat,Strains, Inbred Rat
D002766 Cholecystokinin A peptide, of about 33 amino acids, secreted by the upper INTESTINAL MUCOSA and also found in the central nervous system. It causes gallbladder contraction, release of pancreatic exocrine (or digestive) enzymes, and affects other gastrointestinal functions. Cholecystokinin may be the mediator of satiety. Pancreozymin,CCK-33,Cholecystokinin 33,Uropancreozymin
D004298 Dopamine One of the catecholamine NEUROTRANSMITTERS in the brain. It is derived from TYROSINE and is the precursor to NOREPINEPHRINE and EPINEPHRINE. Dopamine is a major transmitter in the extrapyramidal system of the brain, and important in regulating movement. A family of receptors (RECEPTORS, DOPAMINE) mediate its action. Hydroxytyramine,3,4-Dihydroxyphenethylamine,4-(2-Aminoethyl)-1,2-benzenediol,Dopamine Hydrochloride,Intropin,3,4 Dihydroxyphenethylamine,Hydrochloride, Dopamine
D006892 Hydroxydopamines Dopamines with a hydroxy group substituted in one or more positions. Hydroxydopamine
D000818 Animals Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA. Animal,Metazoa,Animalia
D012686 Septal Nuclei Neural nuclei situated in the septal region. They have afferent and cholinergic efferent connections with a variety of FOREBRAIN and BRAIN STEM areas including the HIPPOCAMPAL FORMATION, the LATERAL HYPOTHALAMUS, the tegmentum, and the AMYGDALA. Included are the dorsal, lateral, medial, and triangular septal nuclei, septofimbrial nucleus, nucleus of diagonal band, nucleus of anterior commissure, and the nucleus of stria terminalis. Bed Nucleus of Stria Terminalis,Nucleus of Anterior Commissure,Nucleus of Diagonal Band,Nucleus of Stria Terminalis,Septofimbrial Nucleus,Dorsal Septal Nucleus,Lateral Septal Nucleus,Lateral Septum Nucleus,Medial Septal Nucleus,Medial Septum Nucleus,Nucleus Interstitialis Striae Terminalis,Nucleus Lateralis Septi,Nucleus Septalis Lateralis,Nucleus Septi Lateralis,Nucleus Striae Terminalis,Nucleus Triangularis Septi,Nucleus of the Stria Terminalis,Septal Nuclear Complex,Triangular Septal Nucleus,Anterior Commissure Nucleus,Complex, Septal Nuclear,Complices, Septal Nuclear,Diagonal Band Nucleus,Laterali, Nucleus Septalis,Laterali, Nucleus Septi,Lateralis Septi, Nucleus,Lateralis Septus, Nucleus,Lateralis, Nucleus Septalis,Lateralis, Nucleus Septi,Nuclear Complex, Septal,Nuclear Complices, Septal,Nuclei, Septal,Nucleus Lateralis Septus,Nucleus Septalis Laterali,Nucleus Septi Laterali,Nucleus Striae Terminali,Nucleus Triangularis Septus,Nucleus, Dorsal Septal,Nucleus, Lateral Septal,Nucleus, Lateral Septum,Nucleus, Medial Septal,Nucleus, Medial Septum,Nucleus, Septofimbrial,Nucleus, Triangular Septal,Septal Nuclear Complices,Septal Nucleus, Dorsal,Septal Nucleus, Lateral,Septal Nucleus, Medial,Septal Nucleus, Triangular,Septalis Laterali, Nucleus,Septalis Lateralis, Nucleus,Septi Laterali, Nucleus,Septi Lateralis, Nucleus,Septi, Nucleus Lateralis,Septi, Nucleus Triangularis,Septum Nucleus, Lateral,Septum Nucleus, Medial,Septus, Nucleus Lateralis,Septus, Nucleus Triangularis,Stria Terminalis Nucleus,Striae Terminali, Nucleus,Striae Terminalis, Nucleus,Terminali, Nucleus Striae,Terminalis, Nucleus Striae,Triangularis Septi, Nucleus,Triangularis Septus, Nucleus
D013681 Tegmentum Mesencephali Portion of midbrain situated under the dorsal TECTUM MESENCEPHALI. The two ventrolateral cylindrical masses or peduncles are large nerve fiber bundles providing a tract of passage between the FOREBRAIN with the HINDBRAIN. Ventral MIDBRAIN also contains three colorful structures: the GRAY MATTER (PERIAQUEDUCTAL GRAY), the black substance (SUBSTANTIA NIGRA), and the RED NUCLEUS. Accessory Oculomotor Nuclei,Annular Nucleus,Darkshevich's Nucleus,Interstitial Nucleus of Cajal,Mesencephalic Tegmentum,Mesencephalic Trigeminal Nucleus,Midbrain Tegmentum,Midbrain Trigeminal Nucleus,Nucleus Annularis,Nucleus Nervi Trochlearis,Nucleus Sagulum,Nucleus Tractus Mesencephalici Nervi Trigemini,Nucleus of Darkschewitsch,Peripeduncular Nucleus,Sagulum Nucleus,Tegmentum of Midbrain,Trochlear Nucleus,Ventral Tegmental Nucleus,Annulari, Nucleus,Annularis, Nucleus,Cajal Interstitial Nucleus,Darkschewitsch Nucleus,Darkshevich Nucleus,Darkshevichs Nucleus,Mesencephali, Tegmentum,Mesencephalic Tegmentums,Mesencephalus, Tegmentum,Midbrain Tegmentums,Nervi Trochleari, Nucleus,Nervi Trochlearis, Nucleus,Nuclei, Accessory Oculomotor,Nucleus Annulari,Nucleus Nervi Trochleari,Nucleus Sagulums,Nucleus, Annular,Nucleus, Darkshevich's,Nucleus, Mesencephalic Trigeminal,Nucleus, Midbrain Trigeminal,Nucleus, Peripeduncular,Nucleus, Sagulum,Nucleus, Trochlear,Nucleus, Ventral Tegmental,Oculomotor Nuclei, Accessory,Sagulum, Nucleus,Sagulums, Nucleus,Tegmental Nucleus, Ventral,Tegmentum Mesencephalus,Tegmentum, Mesencephalic,Tegmentum, Midbrain,Tegmentums, Mesencephalic,Tegmentums, Midbrain,Trigeminal Nucleus, Mesencephalic,Trigeminal Nucleus, Midbrain,Trochleari, Nucleus Nervi,Trochlearis, Nucleus Nervi

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