Levamisole, a wide spectrum antihelminthic has been compared for its, curative effect on condylomata acuminata with podophyhin when given alone or combind with podophylfin topically. A cure rate of83.6% was obtained with podophyllin alone after in average Of 1.6 applications. With combined therapy, comparable good, results- were. Obtained i.e. a cure rate of 79.0% after applications. Levamisole was found to tie completely disappointing and had no effect on warts either given alone or in combination with podophyllin. No serious local or system side effects were noted with podophyllin and levamisole. Perianal and intraameatal warts were found to be relatively resistant to therapy.