Two-dimensional (2D) spin-echo (SE) sequences and three-dimensional (3D) FISP (fast imaging with steady precession) sequences of the knee with the same section thickness and field of view were directly compared in 54 patients, 17 of whom underwent subsequent follow-up (15 arthroscopic and two arthrographic examinations). In those patients with follow-up, each sequence demonstrated 100% sensitivity, 80% specificity, and 94% accuracy for evaluation of the medial meniscus and 100% sensitivity, 100% specificity, and 100% accuracy for evaluation of the lateral meniscus. SE imaging demonstrated 100% sensitivity, 100% specificity, and 100% accuracy for evaluation of the anterior cruciate ligament, while 100% sensitivity, 82% specificity, and 88% accuracy were achieved with FISP imaging. In the 37 patients without follow-up, only two discrepancies were found between the 2D SE and the 3D FISP images for meniscal evaluation. Three discrepancies were found in the evaluation of the anterior cruciate ligament, two of which were likely false-positive 3D FISP results. We conclude that 2D SE and 3D FISP imaging provide comparable data for meniscal evaluation. FISP images are slightly less accurate than SE images of comparable resolution for the evaluation of the anterior cruciate ligament.