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Selective IgA deficiency (SIgAD) is the most common primary immunodeficiency, with frequencies ranging from 1:300 to 1:3,000 in populations surveyed in Europe and the US. In the present study we tested 11,576 clinically healthy persons (blood donors and pregnant women) for SIgAD (serum IgA less than 5 mg%). Serum samples were screened by double immunodiffusion with a sheep anti-human alpha-chain (minimal detection level of 30 mg%). Samples showing negative or doubtful reactions were submitted to the radial immunodiffusion test (minimal detection level of 0.5 mg%). For the samples with low or undetectable IgA levels, IgG and IgM concentrations were also determined. We found 12 individuals with SIgAD and 2 with deficiency of the 3 immunoglobulin classes. The prevalence of SIgAD in this Brazilian population (1:965) is equivalent to values reported for other countries.
M M Carneiro-Sampaio, and
S B Carbonare, and
R B Rozentraub, and
M N de Araújo, and
M A Riberiro, and
M H Porto
December 1973,
Vox sanguinis,
M M Carneiro-Sampaio, and
S B Carbonare, and
R B Rozentraub, and
M N de Araújo, and
M A Riberiro, and
M H Porto
September 1982,
Nihon Ketsueki Gakkai zasshi : journal of Japan Haematological Society,
M M Carneiro-Sampaio, and
S B Carbonare, and
R B Rozentraub, and
M N de Araújo, and
M A Riberiro, and
M H Porto
January 1986,
Vox sanguinis,
M M Carneiro-Sampaio, and
S B Carbonare, and
R B Rozentraub, and
M N de Araújo, and
M A Riberiro, and
M H Porto
April 1986,
Wiadomosci lekarskie (Warsaw, Poland : 1960),
M M Carneiro-Sampaio, and
S B Carbonare, and
R B Rozentraub, and
M N de Araújo, and
M A Riberiro, and
M H Porto
January 1975,
Vox sanguinis,
M M Carneiro-Sampaio, and
S B Carbonare, and
R B Rozentraub, and
M N de Araújo, and
M A Riberiro, and
M H Porto
August 1983,
American journal of clinical pathology,
M M Carneiro-Sampaio, and
S B Carbonare, and
R B Rozentraub, and
M N de Araújo, and
M A Riberiro, and
M H Porto
August 1980,
Australian and New Zealand journal of medicine,
M M Carneiro-Sampaio, and
S B Carbonare, and
R B Rozentraub, and
M N de Araújo, and
M A Riberiro, and
M H Porto
April 1977,
Acta pathologica et microbiologica Scandinavica. Section C, Immunology,
M M Carneiro-Sampaio, and
S B Carbonare, and
R B Rozentraub, and
M N de Araújo, and
M A Riberiro, and
M H Porto
November 1982,
Clinical genetics,
M M Carneiro-Sampaio, and
S B Carbonare, and
R B Rozentraub, and
M N de Araújo, and
M A Riberiro, and
M H Porto
April 2009,
Blood transfusion = Trasfusione del sangue,
