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Recognizing the similarity of type I diabetes mellitus to inborn errors of metabolism that have responded to carnitine therapy, we initiated a study of 54 children with type I diabetes mellitus. Examining a fasting blood sample for levels of carnitine, glucose, and glycosylated hemoglobin A1c, and a urine sample for levels of ketones and glucose, we found 13 children were deficient of free carnitine (less than 20 mumol/L) and 30 had elevated acyl carnitine levels (greater than 11 mumol/L). Statistical tests confirmed a significant difference between the diabetic population and normal population for reduced free carnitine, elevated acyl carnitine, and an elevated ratio of acyl carnitine to free carnitine. Also, a significant correlation was found between the levels of urine glucose and ketones and the level of acyl carnitine. Our data indicate that carnitine deficiency and relative insufficiency may be an overlooked component in the management of diabetes.
S C Winter, and
M Simon, and
E M Zorn, and
S Szabo-Aczel, and
W H Vance, and
T O'Hara, and
L Higashi
August 1991,
Klinische Wochenschrift,
S C Winter, and
M Simon, and
E M Zorn, and
S Szabo-Aczel, and
W H Vance, and
T O'Hara, and
L Higashi
July 1985,
Casopis lekaru ceskych,
S C Winter, and
M Simon, and
E M Zorn, and
S Szabo-Aczel, and
W H Vance, and
T O'Hara, and
L Higashi
July 1989,
Ceskoslovenska pediatrie,
S C Winter, and
M Simon, and
E M Zorn, and
S Szabo-Aczel, and
W H Vance, and
T O'Hara, and
L Higashi
January 2005,
Stomatologija,
S C Winter, and
M Simon, and
E M Zorn, and
S Szabo-Aczel, and
W H Vance, and
T O'Hara, and
L Higashi
August 1990,
Ceskoslovenska pediatrie,
S C Winter, and
M Simon, and
E M Zorn, and
S Szabo-Aczel, and
W H Vance, and
T O'Hara, and
L Higashi
February 1984,
Australian journal of ophthalmology,
S C Winter, and
M Simon, and
E M Zorn, and
S Szabo-Aczel, and
W H Vance, and
T O'Hara, and
L Higashi
October 1982,
Clinica chimica acta; international journal of clinical chemistry,
S C Winter, and
M Simon, and
E M Zorn, and
S Szabo-Aczel, and
W H Vance, and
T O'Hara, and
L Higashi
November 2001,
Clinical biochemistry,
S C Winter, and
M Simon, and
E M Zorn, and
S Szabo-Aczel, and
W H Vance, and
T O'Hara, and
L Higashi
January 1988,
The Diabetes educator,
S C Winter, and
M Simon, and
E M Zorn, and
S Szabo-Aczel, and
W H Vance, and
T O'Hara, and
L Higashi
September 2007,
Pediatric radiology,
