Biomaterial Database

Newer technique of laryngeal reinnervation: superior laryngeal nerve (motor branch) as a driver of the posterior cricoarytenoid muscle. 1989

A J Maniglia, and B Dodds, and K Sorensen, and M B Katirji, and M L Rosenbaum

Department of Otolaryngology-Head and Neck Surgery, Case Western Reserve University School of Medicine, Cleveland, OH.

This report analyzes the experience gained using two different techniques to reinnervate the paralyzed vocal cord. In the neurotization group, the superior laryngeal nerve (SLN) motor branch-cricothyroid muscle pedicle was used to reinnervate the posterior cricoarytenoid muscle. In the direct nerve anastomosis group, the SLN was anastomosed to the abductor branch of the recurrent laryngeal nerve (RLN), and the ansa hypoglossi (AH) to the adductor branch of the RLN. A third group of animals (control) had the right RLN sectioned without any anastomosis. About 5 to 6 months postoperatively the animals were killed painlessly and evaluated. The neurotization group revealed vocal fold mobilization on the right side to have an average of about half of the mobility of the left, normal side. After the RLN and SLN on the left were severed as well as the AH bilaterally, the vocal cord mobility was reduced to about one fourth. The direct nerve anastomosis group showed about fourfold less vocal cord mobility than the neurotization group. After the SLN, RLN, and AH were severed bilaterally, the control group showed no vocal cord mobility. The neurotization technique has been selected for further experimentation in human adults.

UI	MeSH Term	Description	Entries
D007821	Laryngeal Muscles	The striated muscle groups which move the LARYNX as a whole or its parts, such as altering tension of the VOCAL CORDS, or size of the slit (RIMA GLOTTIDIS).	Cricothyroid Muscles,Aryepiglottic Muscle,Arytenoid Muscle,Cricoarytenoid Muscles,Thyroarytenoid Muscles,Thyroepiglottic Muscle,Vocal Muscle,Vocalis Muscle,Aryepiglottic Muscles,Arytenoid Muscles,Cricoarytenoid Muscle,Cricothyroid Muscle,Laryngeal Muscle,Muscle, Aryepiglottic,Muscle, Arytenoid,Muscle, Cricoarytenoid,Muscle, Cricothyroid,Muscle, Laryngeal,Muscle, Thyroarytenoid,Muscle, Thyroepiglottic,Muscle, Vocal,Muscle, Vocalis,Muscles, Aryepiglottic,Muscles, Arytenoid,Muscles, Cricoarytenoid,Muscles, Cricothyroid,Muscles, Laryngeal,Muscles, Thyroarytenoid,Muscles, Thyroepiglottic,Muscles, Vocal,Muscles, Vocalis,Thyroarytenoid Muscle,Thyroepiglottic Muscles,Vocal Muscles,Vocalis Muscles
D007823	Laryngeal Nerves	Branches of the VAGUS NERVE. The superior laryngeal nerves originate near the nodose ganglion and separate into external branches, which supply motor fibers to the cricothyroid muscles, and internal branches, which carry sensory fibers. The RECURRENT LARYNGEAL NERVE originates more caudally and carries efferents to all muscles of the larynx except the cricothyroid. The laryngeal nerves and their various branches also carry sensory and autonomic fibers to the laryngeal, pharyngeal, tracheal, and cardiac regions.	Laryngeal Nerve, Superior,Laryngeal Nerve,Laryngeal Nerves, Superior,Nerve, Laryngeal,Nerve, Superior Laryngeal,Nerves, Laryngeal,Nerves, Superior Laryngeal,Superior Laryngeal Nerve,Superior Laryngeal Nerves
D009132	Muscles	Contractile tissue that produces movement in animals.	Muscle Tissue,Muscle,Muscle Tissues,Tissue, Muscle,Tissues, Muscle
D012009	Recurrent Laryngeal Nerve	Branches of the vagus (tenth cranial) nerve. The recurrent laryngeal nerves originate more caudally than the superior laryngeal nerves and follow different paths on the right and left sides. They carry efferents to all muscles of the larynx except the cricothyroid and carry sensory and autonomic fibers to the laryngeal, pharyngeal, tracheal, and cardiac regions.	Laryngeal Nerve, Inferior,Inferior Laryngeal Nerve,Inferior Laryngeal Nerves,Laryngeal Nerve, Recurrent,Laryngeal Nerves, Inferior,Laryngeal Nerves, Recurrent,Nerve, Inferior Laryngeal,Nerve, Recurrent Laryngeal,Nerves, Inferior Laryngeal,Nerves, Recurrent Laryngeal,Recurrent Laryngeal Nerves
D004285	Dogs	The domestic dog, Canis familiaris, comprising about 400 breeds, of the carnivore family CANIDAE. They are worldwide in distribution and live in association with people. (Walker's Mammals of the World, 5th ed, p1065)	Canis familiaris,Dog
D000714	Anastomosis, Surgical	Surgical union or shunt between ducts, tubes or vessels. It may be end-to-end, end-to-side, side-to-end, or side-to-side.	Surgical Anastomosis,Anastomoses, Surgical,Surgical Anastomoses
D000818	Animals	Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA.	Animal,Metazoa,Animalia
D014826	Vocal Cord Paralysis	Congenital or acquired paralysis of one or both VOCAL CORDS. This condition is caused by defects in the CENTRAL NERVOUS SYSTEM, the VAGUS NERVE and branches of LARYNGEAL NERVES. Common symptoms are VOICE DISORDERS including HOARSENESS or APHONIA.	Laryngeal Nerve Palsy, Recurrent,Laryngeal Paralysis,Acquired Vocal Cord Palsy,Bilateral Vocal Cord Paresis,Congenital Vocal Cord Palsy,Paralysis, Unilateral, Vocal Cord,Paralysis, Vocal Cord, Unilateral,Partial Paralysis (Paresis) Vocal Cords,Recurrent Laryngeal Nerve Palsy,Total Vocal Cord Paralysis,Unilateral Paralysis, Vocal Cord,Unilateral Vocal Cord Paralysis,Unilateral Vocal Cord Paresis,Vocal Cord Palsy,Vocal Cord Palsy, Congenital,Vocal Cord Paralysis, Unilateral,Vocal Cord Paresis,Vocal Fold Palsy,Laryngeal Paralyses,Palsies, Vocal Cord,Palsies, Vocal Fold,Palsy, Vocal Cord,Palsy, Vocal Fold,Paralyses, Laryngeal,Paralyses, Vocal Cord,Paralysis, Laryngeal,Paralysis, Vocal Cord,Pareses, Vocal Cord,Paresis, Vocal Cord,Vocal Cord Palsies,Vocal Cord Paralyses,Vocal Cord Pareses,Vocal Fold Palsies