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Thymopoietin and thymopentin are well characterized polypeptides influencing immunoregulation by several mechanisms. Proposed as a therapy in diseases with major immune abnormalities such as rheumatoid arthritis, thymopentin improved within 2 weeks some clinical parameters as pain and joint swelling. The hypothesis that this spectacular effect could be mediated through interactions with anti-inflammatory (ACTH) and pain relieving (beta-endorphin) hormones producing cells was tested on the rat isolated pituitary cell model. Thymopentin and thymopoietin can enhance in vitro the levels of ACTH, beta-endorphin and beta-lipotropin in a time- and dose-dependent fashion for physiological concentrations ranging from 10(-12) to 10(-8) mol/l. The action on pituitary cells was restricted to those molecules as no changes occurred in LH, FSH, GH, TSH and PRL levels, after otherwise identical experimental conditions.
M G Malaise, and
M T Hazee-Hagelstein, and
A M Reuter, and
Y Vrinds-Gevaert, and
G Goldstein, and
P Franchimont
April 1981,
Brain research,
M G Malaise, and
M T Hazee-Hagelstein, and
A M Reuter, and
Y Vrinds-Gevaert, and
G Goldstein, and
P Franchimont
June 1978,
FEBS letters,
M G Malaise, and
M T Hazee-Hagelstein, and
A M Reuter, and
Y Vrinds-Gevaert, and
G Goldstein, and
P Franchimont
January 1983,
Gynecologic and obstetric investigation,
M G Malaise, and
M T Hazee-Hagelstein, and
A M Reuter, and
Y Vrinds-Gevaert, and
G Goldstein, and
P Franchimont
January 1988,
Life sciences,
M G Malaise, and
M T Hazee-Hagelstein, and
A M Reuter, and
Y Vrinds-Gevaert, and
G Goldstein, and
P Franchimont
November 1980,
Life sciences,
M G Malaise, and
M T Hazee-Hagelstein, and
A M Reuter, and
Y Vrinds-Gevaert, and
G Goldstein, and
P Franchimont
September 1983,
The Tohoku journal of experimental medicine,
M G Malaise, and
M T Hazee-Hagelstein, and
A M Reuter, and
Y Vrinds-Gevaert, and
G Goldstein, and
P Franchimont
January 1980,
Hormone research,
M G Malaise, and
M T Hazee-Hagelstein, and
A M Reuter, and
Y Vrinds-Gevaert, and
G Goldstein, and
P Franchimont
July 1978,
Proceedings of the National Academy of Sciences of the United States of America,
M G Malaise, and
M T Hazee-Hagelstein, and
A M Reuter, and
Y Vrinds-Gevaert, and
G Goldstein, and
P Franchimont
January 1980,
Hormone research,
M G Malaise, and
M T Hazee-Hagelstein, and
A M Reuter, and
Y Vrinds-Gevaert, and
G Goldstein, and
P Franchimont
September 1978,
European journal of pharmacology,
