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Mouse monoclonal antibody c 143 was purified and F(ab')2 fragments were generated by pepsin digestion and then radiolabeled with 125I. The 125I-labeled c 143 F(ab')2 fragments were injected into athymic mice bearing bovine lymphoid tumor cells. The fragments became preferentially localized in tumor tissues, but not in normal tissues, as determined by differential counting of tissue radioactivity. The fragments became localized specifically in those tumors that were reactive with c 143 in vitro, but did not become localized in unrelated tumors. Localization of labeled F(ab')2 fragments of a monoclonal antibody of the same isotype directed against Taka virus (a variant of Newcastle disease virus) was not observed in athymic mice bearing bovine lymphoid tumor cells. Tumors were detectable by radioimmunoscintigraphy, using radiolabeled c 143 F(ab')2 fragments, without background subtraction, and by use of silver-grain scattering in light microscopic autoradiography.
Y Aida, and
K Ochiai, and
K Ito, and
M Onuma, and
F Fujimori, and
Y Fujimoto, and
H Izawa
February 1983,
Cancer research,
Y Aida, and
K Ochiai, and
K Ito, and
M Onuma, and
F Fujimori, and
Y Fujimoto, and
H Izawa
November 1990,
Cancer research,
Y Aida, and
K Ochiai, and
K Ito, and
M Onuma, and
F Fujimori, and
Y Fujimoto, and
H Izawa
December 1992,
Nihon Geka Gakkai zasshi,
Y Aida, and
K Ochiai, and
K Ito, and
M Onuma, and
F Fujimori, and
Y Fujimoto, and
H Izawa
January 1977,
Research in veterinary science,
Y Aida, and
K Ochiai, and
K Ito, and
M Onuma, and
F Fujimori, and
Y Fujimoto, and
H Izawa
March 1985,
Cancer research,
Y Aida, and
K Ochiai, and
K Ito, and
M Onuma, and
F Fujimori, and
Y Fujimoto, and
H Izawa
January 1982,
Cancer detection and prevention,
Y Aida, and
K Ochiai, and
K Ito, and
M Onuma, and
F Fujimori, and
Y Fujimoto, and
H Izawa
May 1986,
Journal of the National Cancer Institute,
Y Aida, and
K Ochiai, and
K Ito, and
M Onuma, and
F Fujimori, and
Y Fujimoto, and
H Izawa
February 1993,
Leukemia research,
Y Aida, and
K Ochiai, and
K Ito, and
M Onuma, and
F Fujimori, and
Y Fujimoto, and
H Izawa
April 1988,
Nihon juigaku zasshi. The Japanese journal of veterinary science,
Y Aida, and
K Ochiai, and
K Ito, and
M Onuma, and
F Fujimori, and
Y Fujimoto, and
H Izawa
September 1987,
American journal of veterinary research,
