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Neurokinin A (NKA) and B (NKB) were more potent bronchoconstrictive agents than substance P (SP) in guinea pig tracheal strips. The content of NKA in guinea pig lung homogenate was 2.26 +/- 1.09 pmol/g wet lung, which was approximately half that of SP (4.46 +/- 1.33 pmol/g wet lung); NKB was not detected in the guinea pig lung homogenate (less than 0.01 pmol/g wet lung). Histologically, NKA-immunoreactive fibers were distributed in the bronchial smooth muscle layers. Pulmonary arteries and veins were also found to be innervated by NKA-immunoreactive nerves. In addition, a few fibers were observed in the trachea, bronchioles, and alveoli. These findings suggest that NKA may be one of the neurotransmitters of the noncholinergic bronchoconstrictive nerves.
Y Uchida, and
A Nomura, and
M Ohtsuka, and
S Hasegawa, and
K Goto, and
S Kimura, and
Y Sugita, and
Y Uchiyama
August 1991,
Journal of applied physiology (Bethesda, Md. : 1985),
Y Uchida, and
A Nomura, and
M Ohtsuka, and
S Hasegawa, and
K Goto, and
S Kimura, and
Y Sugita, and
Y Uchiyama
November 1997,
The Journal of pharmacology and experimental therapeutics,
Y Uchida, and
A Nomura, and
M Ohtsuka, and
S Hasegawa, and
K Goto, and
S Kimura, and
Y Sugita, and
Y Uchiyama
January 1989,
Drugs,
Y Uchida, and
A Nomura, and
M Ohtsuka, and
S Hasegawa, and
K Goto, and
S Kimura, and
Y Sugita, and
Y Uchiyama
July 1974,
Nature,
Y Uchida, and
A Nomura, and
M Ohtsuka, and
S Hasegawa, and
K Goto, and
S Kimura, and
Y Sugita, and
Y Uchiyama
January 2002,
Pulmonary pharmacology & therapeutics,
Y Uchida, and
A Nomura, and
M Ohtsuka, and
S Hasegawa, and
K Goto, and
S Kimura, and
Y Sugita, and
Y Uchiyama
October 1980,
Prostaglandins,
Y Uchida, and
A Nomura, and
M Ohtsuka, and
S Hasegawa, and
K Goto, and
S Kimura, and
Y Sugita, and
Y Uchiyama
March 1989,
The Journal of allergy and clinical immunology,
Y Uchida, and
A Nomura, and
M Ohtsuka, and
S Hasegawa, and
K Goto, and
S Kimura, and
Y Sugita, and
Y Uchiyama
November 1993,
The European respiratory journal,
Y Uchida, and
A Nomura, and
M Ohtsuka, and
S Hasegawa, and
K Goto, and
S Kimura, and
Y Sugita, and
Y Uchiyama
July 1990,
Journal of medicinal chemistry,
Y Uchida, and
A Nomura, and
M Ohtsuka, and
S Hasegawa, and
K Goto, and
S Kimura, and
Y Sugita, and
Y Uchiyama
January 1973,
Pneumonologie. Pneumonology,
