-transparent.png){kind=logo}
A short-term in vitro chemosensitivity test has been applied to 131 specimens from 109 children with various malignancies. The clinical outcome was correlated with in vitro percentage inhibition (PI) of DNA synthesis by the drug tested. In 62 correlations, PIs of responsive and of resistant patients differed significantly, with a cut-off value of 37%. The test predicted clinical resistance in 53/54 cases, with a specificity of 98%, and clinical response in 8/8 cases, with a sensitivity of 100%. This test can be useful particularly in predicting chemoresistance in relapsing patients, to avoid unnecessary toxicity.
Related Publications
C Rosanda, and
A Garaventa, and
M Pasino, and
P Strigini, and
B De Bernardi
February 1987,
Tumori,
C Rosanda, and
A Garaventa, and
M Pasino, and
P Strigini, and
B De Bernardi
September 1982,
Clinical chemistry,
C Rosanda, and
A Garaventa, and
M Pasino, and
P Strigini, and
B De Bernardi
January 1986,
The American journal of pediatric hematology/oncology,
C Rosanda, and
A Garaventa, and
M Pasino, and
P Strigini, and
B De Bernardi
August 1985,
Cancer,
C Rosanda, and
A Garaventa, and
M Pasino, and
P Strigini, and
B De Bernardi
November 1954,
Annals of the New York Academy of Sciences,
C Rosanda, and
A Garaventa, and
M Pasino, and
P Strigini, and
B De Bernardi
April 1988,
Tumori,
C Rosanda, and
A Garaventa, and
M Pasino, and
P Strigini, and
B De Bernardi
November 1983,
American journal of hematology,
C Rosanda, and
A Garaventa, and
M Pasino, and
P Strigini, and
B De Bernardi
February 1987,
Gan to kagaku ryoho. Cancer & chemotherapy,
C Rosanda, and
A Garaventa, and
M Pasino, and
P Strigini, and
B De Bernardi
January 1984,
Recent results in cancer research. Fortschritte der Krebsforschung. Progres dans les recherches sur le cancer,
C Rosanda, and
A Garaventa, and
M Pasino, and
P Strigini, and
B De Bernardi
March 1988,
Cancer,
