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Since antibodies to polyalbumin have been noted to occur in patients with hepatitis or cirrhosis, we investigated sera from 219 patients with a variety of acute and chronic liver diseases with and without HBsAg using an ELISA. The prevalence of circulating polyalbumin antibodies was shown to be significantly increased over that of healthy controls (6.7%) in patients with autoimmune chronic active hepatitis (67%), acute viral hepatitis (41%) and fulminant hepatic necrosis (38%), but such antibodies were absent in chronic hepatitis B patients and other liver diseases. Serial studies in acute hepatitis showed evidence of antibodies early in the course of illness with disappearance prior to full recovery. In acute hepatitis B, the presence of polyalbumin antibodies was significantly associated with female sex (p less than 0.01), 3-fold higher transaminase levels and shorter duration of clinical illness (less than 4 weeks in all cases). Polyalbumin antibodies appear to be associated with diseases characterized by active hepatocyte necrosis. Since they are evident early in acute hepatitis B when complexes of polyalbumin and virus are likely, these antibodies may play an adjunctive role to other hepatitis B-related antibodies in the clearance of hepatitis B virus infection.
W M Lee, and
L McLeod, and
K Martin, and
D L Emerson, and
R M Galbraith
January 1983,
Revista de medicina interna, neurologe, psihiatrie, neurochirurgie, dermato-venerologie. Medicina interna,
W M Lee, and
L McLeod, and
K Martin, and
D L Emerson, and
R M Galbraith
August 1983,
Journal of immunological methods,
W M Lee, and
L McLeod, and
K Martin, and
D L Emerson, and
R M Galbraith
November 1984,
Leber, Magen, Darm,
W M Lee, and
L McLeod, and
K Martin, and
D L Emerson, and
R M Galbraith
March 1985,
The Journal of allergy and clinical immunology,
W M Lee, and
L McLeod, and
K Martin, and
D L Emerson, and
R M Galbraith
February 1983,
Gastroenterology,
W M Lee, and
L McLeod, and
K Martin, and
D L Emerson, and
R M Galbraith
September 1989,
Digestive diseases and sciences,
W M Lee, and
L McLeod, and
K Martin, and
D L Emerson, and
R M Galbraith
January 1987,
La Ricerca in clinica e in laboratorio,
W M Lee, and
L McLeod, and
K Martin, and
D L Emerson, and
R M Galbraith
February 1971,
Immunology,
W M Lee, and
L McLeod, and
K Martin, and
D L Emerson, and
R M Galbraith
January 2011,
Biotechnology progress,
W M Lee, and
L McLeod, and
K Martin, and
D L Emerson, and
R M Galbraith
August 1978,
Zeitschrift fur die gesamte innere Medizin und ihre Grenzgebiete,
