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The use of exogeneous DNA probes, which replicate extrachromosomally, is proposed in order to study spontaneous and induced mutagenesis in mammalian cells. Simian virus 40 has already proved to be very useful, since it has provided much important information in this field. Recently, several shuttle vectors have been designed for this purpose; however, it seems that these molecules have high spontaneous mutation frequencies when replicating in mammalian cells. We have developed new alternative systems, such as Epstein-Barr virus-based shuttle vectors that can be episomally maintained in human cells. Furthermore, we have constructed packageable shuttle vectors, which appear to be stable in the host cell and thus suitable for analysis of mutagenesis.
C F Menck, and
M R James, and
A Gentil, and
A Sarasin
January 1989,
Mutation research,
C F Menck, and
M R James, and
A Gentil, and
A Sarasin
December 1996,
Mutation research,
C F Menck, and
M R James, and
A Gentil, and
A Sarasin
January 1986,
Progress in clinical and biological research,
C F Menck, and
M R James, and
A Gentil, and
A Sarasin
April 1989,
Journal of photochemistry and photobiology. B, Biology,
C F Menck, and
M R James, and
A Gentil, and
A Sarasin
October 1988,
Journal of virology,
C F Menck, and
M R James, and
A Gentil, and
A Sarasin
January 1991,
Progress in clinical and biological research,
C F Menck, and
M R James, and
A Gentil, and
A Sarasin
September 1988,
Molecular and cellular biology,
C F Menck, and
M R James, and
A Gentil, and
A Sarasin
July 1987,
Somatic cell and molecular genetics,
C F Menck, and
M R James, and
A Gentil, and
A Sarasin
January 1982,
Proceedings of the National Academy of Sciences of the United States of America,
C F Menck, and
M R James, and
A Gentil, and
A Sarasin
November 1983,
Analytical biochemistry,
