Biomaterial Database

Metabolic pathways regulated by p63. 2017

Eleonora Candi, and Artem Smirnov, and Emanuele Panatta, and Anna Maria Lena, and Flavia Novelli, and Mara Mancini, and Giuditta Viticchiè, and Maria Cristina Piro, and Nicola Di Daniele, and Margherita Annicchiarico-Petruzzelli, and Gerry Melino

Department of Experimental Medicine and Surgery, University of Rome "Tor Vergata", Rome, Italy; IDI-IRCCS "Istituto Dermopatico dell'Immacolata", Biochemistry Laboratory, Rome, Italy. Electronic address: candi@uniroma2.it.

The transcription factor p63 belongs to the p53-family and is a master regulator of proliferative potential, lineage specification, and differentiation in epithelia during development and tissue homeostasis. In cancer, p63 contribution is isoform-specific, with both oncogenic and tumour suppressive roles attributed, for ΔNp63 and TAp63, respectively. Recently, p53 and TAp73, in line with other tumour suppressor genes, have emerged as important regulators of energy metabolism and metabolic reprogramming in cancer. To date, p63 contributions in controlling energy metabolism have been partially investigated; given the extensive interaction of the p53 family members, these studies have potential implications in tumour cells for metabolic reprogramming. Here, we review the role of p63 isoforms, TAp63 and ΔNp63, in controlling cell metabolism, focusing on their specific metabolic target genes and their physiological/functional context of action.