OBJECTIVE To explore motor function, health-related quality of life and impact on activities of daily living 5 and 6 years after reperfusion treatment in patients with stroke. METHODS A total of 75 patients with first-time stroke received either thrombectomy or thrombolytic treatment at the Sahlgrenska University Hospital in Gothenburg during an 18-month period in 2009-2010. Follow-up involved questionnaires and clinical examinations, 5 and 6 years post-stroke. The results were compared with an individually matched reference group. RESULTS At follow-up 54 persons with reperfusion-treated stroke were alive, of whom 31 (57%) answered the questionnaires and 16 agreed to a clinical examination. The Stroke Impact Scale showed impact in several areas, with the emotion domain being the most affected. The reperfusion-treated group reported significantly better strength and hand function compared with the reference group. Of those clinically examined, 44% were dependent in activities of daily living and 38% had cognitive impairment. CONCLUSIONS Long-term outcome after reperfusion treatment is relatively good, with treated individuals having better strength and hand function compared with a reference group. However, emotional and cognitive problems persist and need to be addressed.