Monoterpenoid Indole Alkaloids from Kopsia officinalis and the Immunosuppressive Activity of Rhazinilam. 2017

Ting Zeng, and Xiu-Yin Wu, and Shu-Xia Yang, and Wei-Chun Lai, and Shun-Dong Shi, and Qiang Zou, and Yang Liu, and Li-Mei Li
Research Center, Chengdu Medical College , Xindu Avenue 783, Chengdu 610500, People's Republic of China.

Six new monoterpenoid indole alkaloids, kopsinidines C-E (1-3), 11,12-methylenedioxychanofruticosinic acid (4), 12-methoxychanofruticosinic acid (5), and N(4)-methylkopsininate (7), as well as chanofruticosinic acid (6, as a natural product) and 23 known alkaloids, were obtained from the twigs and leaves of Kopsia officinalis. Their structures were characterized by physical data analysis. All isolated compounds were evaluated for their immunosuppressive activity on human T cell proliferation. Rhazinilam (29) significantly inhibited human T cell proliferation activated by anti-CD3/anti-CD28 antibodies (IC50 = 1.0 μM) and alloantigen stimulation (IC50 = 1.1 μM) without obvious cytotoxicity for naïve human T cells and peripheral blood mononuclear cells (0-320 μM). Although it did not affect T cell activation, it induced T cell cycle arrest in the G2/M phase and inhibited proinflammatory cytokine production in activated T cells.

UI MeSH Term Description Entries
D007166 Immunosuppressive Agents Agents that suppress immune function by one of several mechanisms of action. Classical cytotoxic immunosuppressants act by inhibiting DNA synthesis. Others may act through activation of T-CELLS or by inhibiting the activation of HELPER CELLS. While immunosuppression has been brought about in the past primarily to prevent rejection of transplanted organs, new applications involving mediation of the effects of INTERLEUKINS and other CYTOKINES are emerging. Immunosuppressant,Immunosuppressive Agent,Immunosuppressants,Agent, Immunosuppressive,Agents, Immunosuppressive
D007212 Indolizines
D007769 Lactams Cyclic AMIDES formed from aminocarboxylic acids by the elimination of water. Lactims are the enol forms of lactams. Lactam,Lactim,Lactims
D007963 Leukocytes, Mononuclear Mature LYMPHOCYTES and MONOCYTES transported by the blood to the body's extravascular space. They are morphologically distinguishable from mature granulocytic leukocytes by their large, non-lobed nuclei and lack of coarse, heavily stained cytoplasmic granules. Mononuclear Leukocyte,Mononuclear Leukocytes,PBMC Peripheral Blood Mononuclear Cells,Peripheral Blood Human Mononuclear Cells,Peripheral Blood Mononuclear Cell,Peripheral Blood Mononuclear Cells,Leukocyte, Mononuclear
D002453 Cell Cycle The complex series of phenomena, occurring between the end of one CELL DIVISION and the end of the next, by which cellular material is duplicated and then divided between two daughter cells. The cell cycle includes INTERPHASE, which includes G0 PHASE; G1 PHASE; S PHASE; and G2 PHASE, and CELL DIVISION PHASE. Cell Division Cycle,Cell Cycles,Cell Division Cycles,Cycle, Cell,Cycle, Cell Division,Cycles, Cell,Cycles, Cell Division,Division Cycle, Cell,Division Cycles, Cell
D002470 Cell Survival The span of viability of a cell characterized by the capacity to perform certain functions such as metabolism, growth, reproduction, some form of responsiveness, and adaptability. Cell Viability,Cell Viabilities,Survival, Cell,Viabilities, Cell,Viability, Cell
D004365 Drugs, Chinese Herbal Chinese herbal or plant extracts which are used as drugs to treat diseases or promote general well-being. The concept does not include synthesized compounds manufactured in China. Chinese Herbal Drugs,Plant Extracts, Chinese,Chinese Drugs, Plant,Chinese Plant Extracts,Extracts, Chinese Plant,Herbal Drugs, Chinese
D006801 Humans Members of the species Homo sapiens. Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D000470 Alkaloids Organic nitrogenous bases. Many alkaloids of medical importance occur in the animal and vegetable kingdoms, and some have been synthesized. (Grant & Hackh's Chemical Dictionary, 5th ed) Alkaloid,Plant Alkaloid,Plant Alkaloids,Alkaloid, Plant,Alkaloids, Plant
D013601 T-Lymphocytes Lymphocytes responsible for cell-mediated immunity. Two types have been identified - cytotoxic (T-LYMPHOCYTES, CYTOTOXIC) and helper T-lymphocytes (T-LYMPHOCYTES, HELPER-INDUCER). They are formed when lymphocytes circulate through the THYMUS GLAND and differentiate to thymocytes. When exposed to an antigen, they divide rapidly and produce large numbers of new T cells sensitized to that antigen. T Cell,T Lymphocyte,T-Cells,Thymus-Dependent Lymphocytes,Cell, T,Cells, T,Lymphocyte, T,Lymphocyte, Thymus-Dependent,Lymphocytes, T,Lymphocytes, Thymus-Dependent,T Cells,T Lymphocytes,T-Cell,T-Lymphocyte,Thymus Dependent Lymphocytes,Thymus-Dependent Lymphocyte

Related Publications

Ting Zeng, and Xiu-Yin Wu, and Shu-Xia Yang, and Wei-Chun Lai, and Shun-Dong Shi, and Qiang Zou, and Yang Liu, and Li-Mei Li
June 2020, Fitoterapia,
Ting Zeng, and Xiu-Yin Wu, and Shu-Xia Yang, and Wei-Chun Lai, and Shun-Dong Shi, and Qiang Zou, and Yang Liu, and Li-Mei Li
August 2020, Journal of Asian natural products research,
Ting Zeng, and Xiu-Yin Wu, and Shu-Xia Yang, and Wei-Chun Lai, and Shun-Dong Shi, and Qiang Zou, and Yang Liu, and Li-Mei Li
March 2022, Journal of ethnopharmacology,
Ting Zeng, and Xiu-Yin Wu, and Shu-Xia Yang, and Wei-Chun Lai, and Shun-Dong Shi, and Qiang Zou, and Yang Liu, and Li-Mei Li
August 1983, Planta medica,
Ting Zeng, and Xiu-Yin Wu, and Shu-Xia Yang, and Wei-Chun Lai, and Shun-Dong Shi, and Qiang Zou, and Yang Liu, and Li-Mei Li
June 2017, Fitoterapia,
Ting Zeng, and Xiu-Yin Wu, and Shu-Xia Yang, and Wei-Chun Lai, and Shun-Dong Shi, and Qiang Zou, and Yang Liu, and Li-Mei Li
January 2017, The Alkaloids. Chemistry and biology,
Ting Zeng, and Xiu-Yin Wu, and Shu-Xia Yang, and Wei-Chun Lai, and Shun-Dong Shi, and Qiang Zou, and Yang Liu, and Li-Mei Li
April 2023, Natural product research,
Ting Zeng, and Xiu-Yin Wu, and Shu-Xia Yang, and Wei-Chun Lai, and Shun-Dong Shi, and Qiang Zou, and Yang Liu, and Li-Mei Li
November 2020, Journal of Asian natural products research,
Ting Zeng, and Xiu-Yin Wu, and Shu-Xia Yang, and Wei-Chun Lai, and Shun-Dong Shi, and Qiang Zou, and Yang Liu, and Li-Mei Li
May 2021, Chemistry & biodiversity,
Ting Zeng, and Xiu-Yin Wu, and Shu-Xia Yang, and Wei-Chun Lai, and Shun-Dong Shi, and Qiang Zou, and Yang Liu, and Li-Mei Li
June 2022, Journal of Asian natural products research,
Copied contents to your clipboard!