-transparent.png){kind=logo}
A series of derivatives of the 2-deoxy analogue of beta-KDO (2,6-anhydro-3-deoxy-D-glycero-D-talo-octonic acid; ammonium salt, 2) has been synthesised as potential inhibitors of CMP-KDO synthetase, starting from methyl 2,6-anhydro-3-deoxy-4,5:7,8-di-O-isopropylidene-D-glycero-D-talo- octonate and replacing the CO2Me group attached to C-2 variously by CONH2, CONHOH, CH2OH, CH2PO(OH)(O-NH4+), COCH2PO(OH)(O-H3N+pheny), CH2CO2-NH4+, CON-HCH2CO2-NH4+, CONHBn, CONHHexyl, CO2Bn, and CO2Hexyl. Of these derivatives, the hydroxamic acid (CONHOH) was the best inhibitor of CMP-KDO synthetase, but was less potent than 2.
Related Publications
K Luthman, and
A Claesson, and
A M Jansson, and
B G Pring
July 1990,
Carbohydrate research,
K Luthman, and
A Claesson, and
A M Jansson, and
B G Pring
January 1982,
Methods in enzymology,
K Luthman, and
A Claesson, and
A M Jansson, and
B G Pring
July 1999,
Organic letters,
K Luthman, and
A Claesson, and
A M Jansson, and
B G Pring
June 1998,
Glycoconjugate journal,
K Luthman, and
A Claesson, and
A M Jansson, and
B G Pring
August 2012,
Organic & biomolecular chemistry,
K Luthman, and
A Claesson, and
A M Jansson, and
B G Pring
June 2016,
Bioorganic & medicinal chemistry letters,
K Luthman, and
A Claesson, and
A M Jansson, and
B G Pring
December 1989,
Carbohydrate research,
K Luthman, and
A Claesson, and
A M Jansson, and
B G Pring
April 1997,
Infection and immunity,
K Luthman, and
A Claesson, and
A M Jansson, and
B G Pring
December 1986,
The Journal of biological chemistry,
K Luthman, and
A Claesson, and
A M Jansson, and
B G Pring
February 2004,
The Journal of biological chemistry,
