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Fluoranthene, a non-carcinogenic polycyclic aromatic hydrocarbon, inactivates Escherichia coli cells in the presence of near-ultraviolet light (NUV; 300-400 nm). E coli cells carrying defects in the uvrA6 or katF genes are sensitized to inactivation by the simultaneous treatment with fluoranthene and NUV, suggesting that DNA is a target and that hydrogen peroxide is generated. Haemophilus influenzae transforming DNA can be inactivated by the simultaneous treatment with fluoranthene and NUV confirming DNA as a target. Using the photooxidation of imidazole and histidine as probes, fluoranthene was found to generate singlet oxygen in organic and aqueous media. In water, it participated in electron transfer reactions, reducing nitro blue tetrazolium as well as ferricytochrome C. This reduction took place both in the presence of air, where superoxide anion was formed, and under argon. Simultaneous treatment with fluoranthene and NUV was incapable of inducing histidine-independent mutations. Simultaneous treatment with fluoranthene and NUV was incapable of inducing the uvrA gene product as evidenced by the absence of the induction of beta-galactosidase in an E coli operon fusion strain [uvrA215::Mud(Ap,lac)].
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J Kagan, and
M A Shaw, and
G M Moresco, and
E M von Behne, and
H Pu, and
M Bazin, and
R Santus
December 1989,
Applied and environmental microbiology,
R W Tuveson, and
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E M von Behne, and
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May 2001,
Environmental toxicology and chemistry,
R W Tuveson, and
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February 2004,
The Journal of pharmacology and experimental therapeutics,
R W Tuveson, and
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August 2007,
Journal of environmental science and health. Part A, Toxic/hazardous substances & environmental engineering,
R W Tuveson, and
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M A Shaw, and
G M Moresco, and
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February 2008,
Ying yong sheng tai xue bao = The journal of applied ecology,
R W Tuveson, and
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November 2016,
Journal of hazardous materials,
R W Tuveson, and
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March 2013,
Journal of UOEH,
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October 2013,
Ecotoxicology (London, England),
R W Tuveson, and
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January 1980,
Carcinogenesis; a comprehensive survey,
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August 2011,
The Journal of chemical physics,
