BIOMAT Database Logo BIOMAT Database Logo

Correlation of immunocytochemically demonstrated estrogen receptor distribution and histopathologic features in primary breast cancer. 1987

U Berger, and P Wilson, and R A McClelland, and J Davidson, and R C Coombes
Ludwig Institute for Cancer Research, St. George's Hospital Medical School, London, United Kingdom.

Frozen sections of breast cancer specimens from 114 patients were assayed for the presence of estrogen receptor (ER) with an immunocytochemical method (ERICA). Significant positive correlations were found between receptor status and various pathologic features, including better histologic degrees of differentiation (P less than 0.001), smaller tumor cell size (P = 0.001), and lower levels of either tumor necrosis (P less than 0.001) or lymphocytic infiltration (P less than 0.001). There was a significant relationship between tubular formation and ER positivity (P = 0.003). This study confirms the results from some previous studies in which ER, assessed by biochemical means, has shown a correlation with good-prognosis pathologic features.

UI MeSH Term Description Entries
D007150 Immunohistochemistry Histochemical localization of immunoreactive substances using labeled antibodies as reagents. Immunocytochemistry,Immunogold Techniques,Immunogold-Silver Techniques,Immunohistocytochemistry,Immunolabeling Techniques,Immunogold Technics,Immunogold-Silver Technics,Immunolabeling Technics,Immunogold Silver Technics,Immunogold Silver Techniques,Immunogold Technic,Immunogold Technique,Immunogold-Silver Technic,Immunogold-Silver Technique,Immunolabeling Technic,Immunolabeling Technique,Technic, Immunogold,Technic, Immunogold-Silver,Technic, Immunolabeling,Technics, Immunogold,Technics, Immunogold-Silver,Technics, Immunolabeling,Technique, Immunogold,Technique, Immunogold-Silver,Technique, Immunolabeling,Techniques, Immunogold,Techniques, Immunogold-Silver,Techniques, Immunolabeling
D008875 Middle Aged An adult aged 45 - 64 years. Middle Age
D009361 Neoplasm Invasiveness Ability of neoplasms to infiltrate and actively destroy surrounding tissue. Invasiveness, Neoplasm,Neoplasm Invasion,Invasion, Neoplasm
D011960 Receptors, Estrogen Cytoplasmic proteins that bind estrogens and migrate to the nucleus where they regulate DNA transcription. Evaluation of the state of estrogen receptors in breast cancer patients has become clinically important. Estrogen Receptor,Estrogen Receptors,Estrogen Nuclear Receptor,Estrogen Receptor Type I,Estrogen Receptor Type II,Estrogen Receptors Type I,Estrogen Receptors Type II,Receptor, Estrogen Nuclear,Receptors, Estrogen, Type I,Receptors, Estrogen, Type II,Nuclear Receptor, Estrogen,Receptor, Estrogen
D001943 Breast Neoplasms Tumors or cancer of the human BREAST. Breast Cancer,Breast Tumors,Cancer of Breast,Breast Carcinoma,Cancer of the Breast,Human Mammary Carcinoma,Malignant Neoplasm of Breast,Malignant Tumor of Breast,Mammary Cancer,Mammary Carcinoma, Human,Mammary Neoplasm, Human,Mammary Neoplasms, Human,Neoplasms, Breast,Tumors, Breast,Breast Carcinomas,Breast Malignant Neoplasm,Breast Malignant Neoplasms,Breast Malignant Tumor,Breast Malignant Tumors,Breast Neoplasm,Breast Tumor,Cancer, Breast,Cancer, Mammary,Cancers, Mammary,Carcinoma, Breast,Carcinoma, Human Mammary,Carcinomas, Breast,Carcinomas, Human Mammary,Human Mammary Carcinomas,Human Mammary Neoplasm,Human Mammary Neoplasms,Mammary Cancers,Mammary Carcinomas, Human,Neoplasm, Breast,Neoplasm, Human Mammary,Neoplasms, Human Mammary,Tumor, Breast
D002277 Carcinoma A malignant neoplasm made up of epithelial cells tending to infiltrate the surrounding tissues and give rise to metastases. It is a histological type of neoplasm and not a synonym for "cancer." Carcinoma, Anaplastic,Carcinoma, Spindle-Cell,Carcinoma, Undifferentiated,Carcinomatosis,Epithelial Neoplasms, Malignant,Epithelioma,Epithelial Tumors, Malignant,Malignant Epithelial Neoplasms,Neoplasms, Malignant Epithelial,Anaplastic Carcinoma,Anaplastic Carcinomas,Carcinoma, Spindle Cell,Carcinomas,Carcinomatoses,Epithelial Neoplasm, Malignant,Epithelial Tumor, Malignant,Epitheliomas,Malignant Epithelial Neoplasm,Malignant Epithelial Tumor,Malignant Epithelial Tumors,Neoplasm, Malignant Epithelial,Spindle-Cell Carcinoma,Spindle-Cell Carcinomas,Tumor, Malignant Epithelial,Undifferentiated Carcinoma,Undifferentiated Carcinomas
D002285 Carcinoma, Intraductal, Noninfiltrating A noninvasive (noninfiltrating) carcinoma of the breast characterized by a proliferation of malignant epithelial cells confined to the mammary ducts or lobules, without light-microscopy evidence of invasion through the basement membrane into the surrounding stroma. Carcinoma, Intraductal,DCIS,Ductal Carcinoma In Situ,Atypical Ductal Hyperplasia,Intraductal Carcinoma, Noninfiltrating,Atypical Ductal Hyperplasias,Carcinoma, Noninfiltrating Intraductal,Carcinomas, Intraductal,Carcinomas, Noninfiltrating Intraductal,Ductal Hyperplasia, Atypical,Ductal Hyperplasias, Atypical,Hyperplasia, Atypical Ductal,Hyperplasias, Atypical Ductal,Intraductal Carcinoma,Intraductal Carcinomas,Intraductal Carcinomas, Noninfiltrating,Noninfiltrating Intraductal Carcinoma,Noninfiltrating Intraductal Carcinomas
D005260 Female Females
D006801 Humans Members of the species Homo sapiens. Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D000328 Adult A person having attained full growth or maturity. Adults are of 19 through 44 years of age. For a person between 19 and 24 years of age, YOUNG ADULT is available. Adults

Related Publications

U Berger, and P Wilson, and R A McClelland, and J Davidson, and R C Coombes
Correlation between histopathologic features and estrogen receptor status in primary breast cancer.
June 1984, International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics,
U Berger, and P Wilson, and R A McClelland, and J Davidson, and R C Coombes
Correlation of primary breast cancer histopathology and estrogen receptor content.
January 1981, Breast cancer research and treatment,
U Berger, and P Wilson, and R A McClelland, and J Davidson, and R C Coombes
Correlation of an estrogen receptor-related phosphoprotein with histopathological features in breast cancer.
January 1989, The International journal of biological markers,
U Berger, and P Wilson, and R A McClelland, and J Davidson, and R C Coombes
Correlation of estrogen receptor protein and histopathologic characteristics in 175 cases of breast carcinoma.
July 1987, Indian journal of pathology & microbiology,
U Berger, and P Wilson, and R A McClelland, and J Davidson, and R C Coombes
Estrogen receptor and breast MR imaging features: a correlation study.
April 2008, Journal of magnetic resonance imaging : JMRI,
U Berger, and P Wilson, and R A McClelland, and J Davidson, and R C Coombes
Estrogen receptor, progesterone receptor, and nuclear size features in female breast cancer in Libya: correlation with clinical features and survival.
August 2012, Anticancer research,
U Berger, and P Wilson, and R A McClelland, and J Davidson, and R C Coombes
Automated quantitation of immunocytochemically localized estrogen receptors in human breast cancer.
June 1990, Cancer research,
U Berger, and P Wilson, and R A McClelland, and J Davidson, and R C Coombes
Breast Angiosarcoma: Imaging Features With Histopathologic Correlation.
May 2023, Journal of breast imaging,
U Berger, and P Wilson, and R A McClelland, and J Davidson, and R C Coombes
Histopathologic characterization of human breast cancer in correlation with estrogen receptor status. A comparison of immunocytochemical and biochemical analysis.
March 1988, Cancer,
U Berger, and P Wilson, and R A McClelland, and J Davidson, and R C Coombes
Estrogen receptor gene analysis in estrogen receptor-positive and receptor-negative primary breast cancer.
March 1995, Journal of the National Cancer Institute,
Copied contents to your clipboard!