Influence of oestradiol on alpha 2-adrenoceptor binding sites on intact platelets of young male volunteers. 1987

I W Reimann, and C Britzelmeier, and P Haber, and H Wollmann, and K H Antonin, and P R Bieck
Humanpharmakologisches Institut, CIBA-GEIGY, Tübingen, Federal Republic of Germany.

The specific binding (Bmax) of (3H-methyl)yohimbine to alpha 2-adrenoceptor binding sites on intact platelets was increased by 43% in 6 out of 7 young male volunteers 4 days after a single i.m. injection of 10 mg sustained release oestradiol, and it had returned to the starting value 4 weeks after drug administration. Mean plasma oestradiol was 331 pg/ml on Day 4 and it was within the pre-treatment control range of 19 pg/ml 4 weeks after the injection. A close correlation between the post-injection plasma oestradiol concentration and the increase in alpha 2-adrenoceptor binding sites on intact platelets was not found.

UI MeSH Term Description Entries
D008297 Male Males
D011942 Receptors, Adrenergic, alpha One of the two major pharmacological subdivisions of adrenergic receptors that were originally defined by the relative potencies of various adrenergic compounds. The alpha receptors were initially described as excitatory receptors that post-junctionally stimulate SMOOTH MUSCLE contraction. However, further analysis has revealed a more complex picture involving several alpha receptor subtypes and their involvement in feedback regulation. Adrenergic alpha-Receptor,Adrenergic alpha-Receptors,Receptors, alpha-Adrenergic,alpha-Adrenergic Receptor,alpha-Adrenergic Receptors,Receptor, Adrenergic, alpha,Adrenergic alpha Receptor,Adrenergic alpha Receptors,Receptor, alpha-Adrenergic,Receptors, alpha Adrenergic,alpha Adrenergic Receptor,alpha Adrenergic Receptors,alpha-Receptor, Adrenergic,alpha-Receptors, Adrenergic
D001792 Blood Platelets Non-nucleated disk-shaped cells formed in the megakaryocyte and found in the blood of all mammals. They are mainly involved in blood coagulation. Platelets,Thrombocytes,Blood Platelet,Platelet,Platelet, Blood,Platelets, Blood,Thrombocyte
D004958 Estradiol The 17-beta-isomer of estradiol, an aromatized C18 steroid with hydroxyl group at 3-beta- and 17-beta-position. Estradiol-17-beta is the most potent form of mammalian estrogenic steroids. 17 beta-Estradiol,Estradiol-17 beta,Oestradiol,17 beta-Oestradiol,Aerodiol,Delestrogen,Estrace,Estraderm TTS,Estradiol Anhydrous,Estradiol Hemihydrate,Estradiol Hemihydrate, (17 alpha)-Isomer,Estradiol Monohydrate,Estradiol Valerate,Estradiol Valeriante,Estradiol, (+-)-Isomer,Estradiol, (-)-Isomer,Estradiol, (16 alpha,17 alpha)-Isomer,Estradiol, (16 alpha,17 beta)-Isomer,Estradiol, (17-alpha)-Isomer,Estradiol, (8 alpha,17 beta)-(+-)-Isomer,Estradiol, (8 alpha,17 beta)-Isomer,Estradiol, (9 beta,17 alpha)-Isomer,Estradiol, (9 beta,17 beta)-Isomer,Estradiol, Monosodium Salt,Estradiol, Sodium Salt,Estradiol-17 alpha,Estradiol-17beta,Ovocyclin,Progynon-Depot,Progynova,Vivelle,17 beta Estradiol,17 beta Oestradiol,Estradiol 17 alpha,Estradiol 17 beta,Estradiol 17beta,Progynon Depot
D006801 Humans Members of the species Homo sapiens. Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D000328 Adult A person having attained full growth or maturity. Adults are of 19 through 44 years of age. For a person between 19 and 24 years of age, YOUNG ADULT is available. Adults
D015016 Yohimbine A plant alkaloid with alpha-2-adrenergic blocking activity. Yohimbine has been used as a mydriatic and in the treatment of ERECTILE DYSFUNCTION. Rauwolscine,Aphrodine Hydrochloride,Aphrodyne,Corynanthine,Corynanthine Tartrate,Pluriviron,Rauhimbine,Yocon,Yohimbin Spiegel,Yohimbine Houdé,Yohimbine Hydrochloride,Yohimex,Hydrochloride, Aphrodine,Hydrochloride, Yohimbine,Tartrate, Corynanthine

Related Publications

I W Reimann, and C Britzelmeier, and P Haber, and H Wollmann, and K H Antonin, and P R Bieck
July 1983, Life sciences,
I W Reimann, and C Britzelmeier, and P Haber, and H Wollmann, and K H Antonin, and P R Bieck
January 1991, Life sciences,
I W Reimann, and C Britzelmeier, and P Haber, and H Wollmann, and K H Antonin, and P R Bieck
January 1995, Naunyn-Schmiedeberg's archives of pharmacology,
I W Reimann, and C Britzelmeier, and P Haber, and H Wollmann, and K H Antonin, and P R Bieck
April 1994, Investigative ophthalmology & visual science,
I W Reimann, and C Britzelmeier, and P Haber, and H Wollmann, and K H Antonin, and P R Bieck
April 1997, Psychoneuroendocrinology,
I W Reimann, and C Britzelmeier, and P Haber, and H Wollmann, and K H Antonin, and P R Bieck
July 1995, Annals of the New York Academy of Sciences,
I W Reimann, and C Britzelmeier, and P Haber, and H Wollmann, and K H Antonin, and P R Bieck
October 1982, British journal of pharmacology,
I W Reimann, and C Britzelmeier, and P Haber, and H Wollmann, and K H Antonin, and P R Bieck
January 1983, Psychopharmacology,
I W Reimann, and C Britzelmeier, and P Haber, and H Wollmann, and K H Antonin, and P R Bieck
July 1987, British journal of clinical pharmacology,
I W Reimann, and C Britzelmeier, and P Haber, and H Wollmann, and K H Antonin, and P R Bieck
March 1979, Endocrinology,
Copied contents to your clipboard!