Biomaterial Database

CD4 T Follicular Helper Cells and HIV Infection: Friends or Enemies? 2017

Félicien Moukambi, and Vasco Rodrigues, and Yasmina Fortier, and Henintsoa Rabezanahary, and Chloé Borde, and Bernard Krust, and Guadalupe Andreani, and Ricardo Silvestre, and Constantinos Petrovas, and Mireille Laforge, and Jérôme Estaquier

Centre Hospitalier Universitaire (CHU) de Québec Research Center, Faculty of Medicine, Laval University , Québec, QC , Canada.

Follicular T helper (Tfh) cells, a subset of CD4 T lymphocytes, are essential for memory B cell activation, survival, and differentiation and assist B cells in the production of antigen-specific antibodies. Work performed in recent years pointed out the importance of Tfh cells in the context of HIV and SIV infections. The importance of tissue distribution of Tfh is also an important point since their frequency differs between peripheral blood and lymph nodes compared to the spleen, the primary organ for B cell activation, and differentiation. Our recent observations indicated an early and profound loss of splenic Tfh cells. The role of transcriptional activator and repressor factors that control Tfh differentiation is also discussed in the context of HIV/SIV infection. Because Tfh cells are important for B cell differentiation and antibody production, accelerating the Tfh responses early during HIV/SIV infection could be promising as novel immunotherapeutic approach or alternative vaccine strategies. However, because Tfh cells are infected during the HIV/SIV infection and represent a reservoir, this may interfere with HIV vaccine strategy. Thus, Tfh represent the good and bad guys during HIV infection.