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Studies using cultured human adrenocortical cells were performed to determine if the immune modulation of glucocorticoid production previously described in animal studies also occurs in humans. Human monocytes significantly increased (P less than 0.001) cortisol production from adrenocortical cells after 24, 48, and 72 h of culture. This stimulation was not CRH dependent, and the presence of CRH alone did not augment cortisol production. The active factor was soluble, since supernatants of monocyte cultures stimulated cortisol production by adrenocortical cells; ACTH levels in these supernatants were undetectable by RIA. While interleukin-1 also stimulated cortisol production by adrenal cells, the degree of stimulation was only 30% of that in the monocyte experiments. In contrast to previous animal studies, we found that human monocytes stimulate cortisol production by human adrenocortical cells by a factor that is neither CRH dependent nor mediated by immunoreactive ACTH-(1-24) or ACTH-(1-39).
R W Whitcomb, and
W M Linehan, and
L M Wahl, and
R A Knazek
November 1991,
American journal of obstetrics and gynecology,
R W Whitcomb, and
W M Linehan, and
L M Wahl, and
R A Knazek
May 1983,
Thrombosis research,
R W Whitcomb, and
W M Linehan, and
L M Wahl, and
R A Knazek
May 1997,
Endocrinology,
R W Whitcomb, and
W M Linehan, and
L M Wahl, and
R A Knazek
January 1982,
Journal of steroid biochemistry,
R W Whitcomb, and
W M Linehan, and
L M Wahl, and
R A Knazek
November 1990,
Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme,
R W Whitcomb, and
W M Linehan, and
L M Wahl, and
R A Knazek
July 1999,
The Journal of clinical endocrinology and metabolism,
R W Whitcomb, and
W M Linehan, and
L M Wahl, and
R A Knazek
November 1988,
Biochimica et biophysica acta,
R W Whitcomb, and
W M Linehan, and
L M Wahl, and
R A Knazek
October 1984,
Bollettino della Societa italiana di biologia sperimentale,
R W Whitcomb, and
W M Linehan, and
L M Wahl, and
R A Knazek
May 1984,
The Journal of clinical endocrinology and metabolism,
R W Whitcomb, and
W M Linehan, and
L M Wahl, and
R A Knazek
October 1996,
Diabetes,
