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The importance of carbohydrate moieties for the antigenicity of purified soluble Plasmodium falciparum antigens from the asexual blood stage was tested. Digestion of the soluble antigens with alpha-D-galactosidase clearly affected the ability of the antigen to react with malaria-immune sera from different geographical origins in crossed immunoelectrophoresis and immunoblotting. Antigens of 220, 180, 80, and 74 kilodaltons were affected by the enzyme treatment. Furthermore, the enzyme digestion reduced the ability of the purified soluble antigen to stimulate lymphocytes from malaria-immune donors. The results might have important implications for the strategy of developing a malaria vaccine.
P H Jakobsen, and
T G Theander, and
J B Jensen, and
K Mølbak, and
S Jepsen
January 1987,
Parasitology research,
P H Jakobsen, and
T G Theander, and
J B Jensen, and
K Mølbak, and
S Jepsen
February 2001,
Proceedings of the National Academy of Sciences of the United States of America,
P H Jakobsen, and
T G Theander, and
J B Jensen, and
K Mølbak, and
S Jepsen
August 1990,
Immunology letters,
P H Jakobsen, and
T G Theander, and
J B Jensen, and
K Mølbak, and
S Jepsen
April 1984,
Clinical and experimental immunology,
P H Jakobsen, and
T G Theander, and
J B Jensen, and
K Mølbak, and
S Jepsen
January 1991,
Transactions of the Royal Society of Tropical Medicine and Hygiene,
P H Jakobsen, and
T G Theander, and
J B Jensen, and
K Mølbak, and
S Jepsen
November 2018,
FEBS open bio,
P H Jakobsen, and
T G Theander, and
J B Jensen, and
K Mølbak, and
S Jepsen
January 1995,
Medecine tropicale : revue du Corps de sante colonial,
P H Jakobsen, and
T G Theander, and
J B Jensen, and
K Mølbak, and
S Jepsen
January 2022,
Frontiers in immunology,
P H Jakobsen, and
T G Theander, and
J B Jensen, and
K Mølbak, and
S Jepsen
November 1989,
Blood,
P H Jakobsen, and
T G Theander, and
J B Jensen, and
K Mølbak, and
S Jepsen
March 1988,
Clinical and experimental immunology,
