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Characterization of a series of mouse monoclonal antibodies (designated alpha Py C21 to 26) against the region common to the large, middle and small T antigens of polyoma virus has revealed immunological diversities among the N termini of these antigens. Four of the antibodies (alpha Py C21 to 24) appeared to recognize all the T antigens present in lytically infected cells, but two of them (alpha Py C25, 26) failed to immunoprecipitate small T antigen either from 35S- or 32P-labelled cells and recognized only a subset of middle and large T antigens. None of the antibodies recognized the protein kinase activity normally associated with middle T antigen or the 60K mol. wt. antigen-related protein observed in polyoma virus lytically infected or transformed cells. The possible immunodominance of the N termini of the early gene products (as well as VP1) in the natural host of polyoma virus and the observed antigenic heterogeneity are considered.
A J Street, and
B E Griffin
October 1979,
Nucleic acids research,
A J Street, and
B E Griffin
January 1982,
Virology,
A J Street, and
B E Griffin
January 1980,
Cold Spring Harbor symposia on quantitative biology,
A J Street, and
B E Griffin
December 1978,
Proceedings of the National Academy of Sciences of the United States of America,
A J Street, and
B E Griffin
January 1970,
Zeitschrift fur Immunitatsforschung, experimentelle und klinische Immunologie,
A J Street, and
B E Griffin
July 1979,
Tanpakushitsu kakusan koso. Protein, nucleic acid, enzyme,
A J Street, and
B E Griffin
March 1986,
The EMBO journal,
A J Street, and
B E Griffin
August 2009,
Seminars in cancer biology,
