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OBJECTIVE The aim of this study was to investigate the probable effects of Hypericum perforatum (HP) on wound healing in diabetic rats. METHODS Thirty-five male Wistar rats were divided evenly into 5 groups. Diabetes formation was induced by intraperitoneal streptozotocin (60 mg/kg) administration for groups 1 (HP extract in olive oil), 2 (HP extract in ethanol), 3 (povidone-iodine application), and 4 (diabetic rats without any applied medication); group 5 was the control. Dorsal dermoepidermal incision was performed on each rat after 48 hours. The aforementioned solutions were applied only to groups 1, 2, and 3; groups 4 and 5 did not receive solution applications. At the end of the 7-day period, the cutaneous tissue was resected from the center of the incised and sutured region and divided into 3 pieces for biomechanical, biochemical, and histopathological assessments. RESULTS Ultimate stress and toughness significantly decreased in groups 3, 4, and 5 compared to group 1. There was a significant difference between groups 2 and 3 for the same parameters (P < .05). Compared with group 4, tissue malondialdehyde levels were found to be lower in the HP groups (P < .05). Histopathological evaluation revealed the fibroblast count was reduced considerably in the HP-applied rats compared with other groups (P < .05). CONCLUSIONS Application of HP may be recommended as effective on wound healing in diabetic rats, but further investigation is needed to adapt the findings for clinical use.
Mehmet Farsak, and
Görkemo Özdağli, and
Doğay Özmüş, and
Ülkü Çömelekoğlu, and
Serap Yalın, and
Rabia Bozdoğan Arpacı, and
Ramazan Gen, and
Arzu Kanık, and
Derya Ümit Talas
October 2009,
Drug discoveries & therapeutics,
Mehmet Farsak, and
Görkemo Özdağli, and
Doğay Özmüş, and
Ülkü Çömelekoğlu, and
Serap Yalın, and
Rabia Bozdoğan Arpacı, and
Ramazan Gen, and
Arzu Kanık, and
Derya Ümit Talas
January 2011,
Acta poloniae pharmaceutica,
Mehmet Farsak, and
Görkemo Özdağli, and
Doğay Özmüş, and
Ülkü Çömelekoğlu, and
Serap Yalın, and
Rabia Bozdoğan Arpacı, and
Ramazan Gen, and
Arzu Kanık, and
Derya Ümit Talas
September 2018,
European oral research,
Mehmet Farsak, and
Görkemo Özdağli, and
Doğay Özmüş, and
Ülkü Çömelekoğlu, and
Serap Yalın, and
Rabia Bozdoğan Arpacı, and
Ramazan Gen, and
Arzu Kanık, and
Derya Ümit Talas
November 2010,
BMC complementary and alternative medicine,
Mehmet Farsak, and
Görkemo Özdağli, and
Doğay Özmüş, and
Ülkü Çömelekoğlu, and
Serap Yalın, and
Rabia Bozdoğan Arpacı, and
Ramazan Gen, and
Arzu Kanık, and
Derya Ümit Talas
September 2005,
Shock (Augusta, Ga.),
Mehmet Farsak, and
Görkemo Özdağli, and
Doğay Özmüş, and
Ülkü Çömelekoğlu, and
Serap Yalın, and
Rabia Bozdoğan Arpacı, and
Ramazan Gen, and
Arzu Kanık, and
Derya Ümit Talas
July 2011,
Pharmacognosy magazine,
Mehmet Farsak, and
Görkemo Özdağli, and
Doğay Özmüş, and
Ülkü Çömelekoğlu, and
Serap Yalın, and
Rabia Bozdoğan Arpacı, and
Ramazan Gen, and
Arzu Kanık, and
Derya Ümit Talas
August 1993,
Veterinary and human toxicology,
Mehmet Farsak, and
Görkemo Özdağli, and
Doğay Özmüş, and
Ülkü Çömelekoğlu, and
Serap Yalın, and
Rabia Bozdoğan Arpacı, and
Ramazan Gen, and
Arzu Kanık, and
Derya Ümit Talas
January 2013,
Clinical and experimental hypertension (New York, N.Y. : 1993),
Mehmet Farsak, and
Görkemo Özdağli, and
Doğay Özmüş, and
Ülkü Çömelekoğlu, and
Serap Yalın, and
Rabia Bozdoğan Arpacı, and
Ramazan Gen, and
Arzu Kanık, and
Derya Ümit Talas
January 2015,
Evidence-based complementary and alternative medicine : eCAM,
Mehmet Farsak, and
Görkemo Özdağli, and
Doğay Özmüş, and
Ülkü Çömelekoğlu, and
Serap Yalın, and
Rabia Bozdoğan Arpacı, and
Ramazan Gen, and
Arzu Kanık, and
Derya Ümit Talas
October 2011,
Asian Pacific journal of tropical biomedicine,
