-transparent.png){kind=logo}
Proto-oncogene fos, which is expressed during cell growth and cell differentiation and development, is a multifaceted gene. The viral homolog, v-fos, was identified as the resident transforming gene of FBJ-murine osteosarcoma virus, which induces bone tumors in mice. Owing to an in-frame deletion during the biogenesis of the v-fos gene, the products of viral and cellular fos proteins differ at their C-termini. Despite different C-termini, both fos proteins are nuclear in their location and can transform fibroblasts in vitro. However, transformation by the c-fos gene requires removal of a 67-base pair sequence from the 3' noncoding domain. Proto-oncogene fos is a highly inducible gene in response to a variety of growth factors and differentiation-specific inducers. The expression of the fos gene is not modulated during the cell cycle.
R L Mitchell, and
S K Hanks, and
I M Verma
January 1986,
Princess Takamatsu symposia,
R L Mitchell, and
S K Hanks, and
I M Verma
January 1990,
Archiv fur Geschwulstforschung,
R L Mitchell, and
S K Hanks, and
I M Verma
April 1993,
Sheng li ke xue jin zhan [Progress in physiology],
R L Mitchell, and
S K Hanks, and
I M Verma
January 1987,
Oncogene,
R L Mitchell, and
S K Hanks, and
I M Verma
July 1988,
Nature,
R L Mitchell, and
S K Hanks, and
I M Verma
November 1987,
Cell,
R L Mitchell, and
S K Hanks, and
I M Verma
October 1994,
Critical reviews in oncology/hematology,
R L Mitchell, and
S K Hanks, and
I M Verma
January 1987,
Journal of cellular physiology. Supplement,
R L Mitchell, and
S K Hanks, and
I M Verma
December 1995,
Biokhimiia (Moscow, Russia),
R L Mitchell, and
S K Hanks, and
I M Verma
August 1997,
Zhongguo ying yong sheng li xue za zhi = Zhongguo yingyong shenglixue zazhi = Chinese journal of applied physiology,
