Solubility prediction in octanol: A technical note. 2006

Kia Sepassi, and Samuel H Yalkowsky
College of Pharmacy, University of Arizona, 1703 East Mabel St, 85721, Tucson, AZ. sepassi@pharmacy.arizona.edu.

The purpose of this work was to derive an equation for the rapid estimation of octanol solubilities of organic compounds. Solubilities ranging over 4 orders of, magnitude were predicted with an average absolute error of 0.39 logarithmic units using melting point alone. The greatest error in prediction occurred for strongly bonded compounds.

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