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The T-cell surface glycoprotein, CD4 (T4), acts as the cellular receptor for human immunodeficiency virus, type 1 (HIV-1), the first member of the family of viruses that cause acquired immunodeficiency syndrome. HIV recognition of CD4 is probably mediated through the virus envelope glycoprotein (gp120) as shown by co-immunoprecipitation of CD4 and gp120 (ref.5) and by experiments using recombinant gp120 as a binding probe. Here we demonstrate that recombinant soluble CD4(rsT4) purified from the conditioned medium of a stably transfected Chinese hamster ovary cell line is a potent inhibitor of both virus replication and virus-induced cell fusion (syncytium formation). These results suggest that rsT4 is sufficient to bind HIV, and that it represents a potential anti-viral therapy for HIV infection.
R A Fisher, and
J M Bertonis, and
W Meier, and
V A Johnson, and
D S Costopoulos, and
T Liu, and
R Tizard, and
B D Walker, and
M S Hirsch, and
R T Schooley
January 1990,
Biotherapy (Dordrecht, Netherlands),
R A Fisher, and
J M Bertonis, and
W Meier, and
V A Johnson, and
D S Costopoulos, and
T Liu, and
R Tizard, and
B D Walker, and
M S Hirsch, and
R T Schooley
January 1994,
Archives of virology,
R A Fisher, and
J M Bertonis, and
W Meier, and
V A Johnson, and
D S Costopoulos, and
T Liu, and
R Tizard, and
B D Walker, and
M S Hirsch, and
R T Schooley
January 1990,
The Journal of infectious diseases,
R A Fisher, and
J M Bertonis, and
W Meier, and
V A Johnson, and
D S Costopoulos, and
T Liu, and
R Tizard, and
B D Walker, and
M S Hirsch, and
R T Schooley
June 1990,
The Journal of infectious diseases,
R A Fisher, and
J M Bertonis, and
W Meier, and
V A Johnson, and
D S Costopoulos, and
T Liu, and
R Tizard, and
B D Walker, and
M S Hirsch, and
R T Schooley
June 1990,
AIDS research and human retroviruses,
R A Fisher, and
J M Bertonis, and
W Meier, and
V A Johnson, and
D S Costopoulos, and
T Liu, and
R Tizard, and
B D Walker, and
M S Hirsch, and
R T Schooley
May 1990,
AIDS research and human retroviruses,
R A Fisher, and
J M Bertonis, and
W Meier, and
V A Johnson, and
D S Costopoulos, and
T Liu, and
R Tizard, and
B D Walker, and
M S Hirsch, and
R T Schooley
May 1990,
Lancet (London, England),
R A Fisher, and
J M Bertonis, and
W Meier, and
V A Johnson, and
D S Costopoulos, and
T Liu, and
R Tizard, and
B D Walker, and
M S Hirsch, and
R T Schooley
May 1992,
AIDS research and human retroviruses,
R A Fisher, and
J M Bertonis, and
W Meier, and
V A Johnson, and
D S Costopoulos, and
T Liu, and
R Tizard, and
B D Walker, and
M S Hirsch, and
R T Schooley
June 1990,
Journal of immunology (Baltimore, Md. : 1950),
R A Fisher, and
J M Bertonis, and
W Meier, and
V A Johnson, and
D S Costopoulos, and
T Liu, and
R Tizard, and
B D Walker, and
M S Hirsch, and
R T Schooley
September 2019,
PLoS pathogens,
