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Membrane markers (anti-ALL and anti-Ia antisera) and an enzyme marker (terminal transferase) have been used to define an L-type or "lymphoid" type of acute transformation in chronic myeloid leukaemia and Ph1 positive acute leukaemia. Patients with L-type ("lymphoid") blasts responded to regimens including vincristine and prednisolone (VP). The markers showed better correlation with survival than did the morphology of blasts. The clinical course of patients was variable; elimination Ph1 positive clone (and hypoplasia), return to the chronic phase and relapses (including meningeal leukaemia) were observed. In contrast, patients with myeloid blasts ("M" type of blast crisis) failed to respond to vincristine and prednisolone.
G Janossy, and
M Roberts, and
M F Greaves, and
R Woodruff, and
M Pippard, and
G Prentice, and
A V Hoffbrand
June 1983,
British journal of haematology,
G Janossy, and
M Roberts, and
M F Greaves, and
R Woodruff, and
M Pippard, and
G Prentice, and
A V Hoffbrand
November 1977,
British medical journal,
G Janossy, and
M Roberts, and
M F Greaves, and
R Woodruff, and
M Pippard, and
G Prentice, and
A V Hoffbrand
August 2016,
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G Janossy, and
M Roberts, and
M F Greaves, and
R Woodruff, and
M Pippard, and
G Prentice, and
A V Hoffbrand
January 1978,
British medical journal,
G Janossy, and
M Roberts, and
M F Greaves, and
R Woodruff, and
M Pippard, and
G Prentice, and
A V Hoffbrand
November 1977,
British medical journal,
G Janossy, and
M Roberts, and
M F Greaves, and
R Woodruff, and
M Pippard, and
G Prentice, and
A V Hoffbrand
October 1976,
British journal of haematology,
G Janossy, and
M Roberts, and
M F Greaves, and
R Woodruff, and
M Pippard, and
G Prentice, and
A V Hoffbrand
June 1991,
Medicina clinica,
G Janossy, and
M Roberts, and
M F Greaves, and
R Woodruff, and
M Pippard, and
G Prentice, and
A V Hoffbrand
December 1976,
Lancet (London, England),
G Janossy, and
M Roberts, and
M F Greaves, and
R Woodruff, and
M Pippard, and
G Prentice, and
A V Hoffbrand
July 2002,
British journal of haematology,
G Janossy, and
M Roberts, and
M F Greaves, and
R Woodruff, and
M Pippard, and
G Prentice, and
A V Hoffbrand
February 1987,
The Journal of the Association of Physicians of India,
