BIOMAT Database Logo BIOMAT Database Logo

[Pyoderma gangrenosum associated with anti-proteinase 3 antineutrophil cytoplasmic antibodies (PR3-ANCA) induced by propylthiouracil]. 2017

A Coster, and J-L Dargent, and N de Visscher, and P Levecque, and P-P Roquet-Gravy
Département de dermatologie, grand hôpital de Charleroi (GHDC), Grand'Rue 3, 6000 Charleroi, Belgique. Electronic address: alisoncoster@hotmail.com.

BACKGROUND Synthetic antithyroid drugs are often used in the treatment of hyperthyroidism, regardless of aetiology. They may cause various side effects, including the development of anti-neutrophil cytoplasmic antibodies (ANCA), ANCA-associated vasculitis, and neutrophilic dermatoses. Propylthiouracil (PTU) is the antithyroid drug most frequently implicated in ANCA-associated diseases specifically involving anti-myeloperoxidase ANCA (MPO-ANCA). To our knowledge, there are no clinical reports describing the association of pyoderma gangrenosum (PG) and anti-proteinase3-ANCA (PR3-ANCA) induced by PTU, with ANCA levels decreasing after antithyroid drug withdrawal. METHODS A 68-year-old woman was treated with propylthiouracil (PTU) for toxic multinodular goitre. She presented necrotic ulceration of the lower abdomen. The patient's history, physical examination, and bacteriological and histological samples led to a diagnosis of pyoderma gangrenosum. This pyoderma involved ANCA with antigenic specificity for proteinase 3. Withdrawal of PTU and a short course of corticosteroids and cyclosporine resulted in rapid and complete resolution of the pyoderma gangrenosum as well as a decrease in ANCA. No relapse was observed one year after cessation of treatment. CONCLUSIONS We report a case of PG associated with PR3-ANCA induced by PTU, without any demonstrable vasculitis.

UI MeSH Term Description Entries
D006980 Hyperthyroidism Hypersecretion of THYROID HORMONES from the THYROID GLAND. Elevated levels of thyroid hormones increase BASAL METABOLIC RATE. Hyperthyroid,Primary Hyperthyroidism,Hyperthyroidism, Primary,Hyperthyroids
D011441 Propylthiouracil A thiourea antithyroid agent. Propythiouracil inhibits the synthesis of thyroxine and inhibits the peripheral conversion of throxine to tri-iodothyronine. It is used in the treatment of hyperthyroidism. (From Martindale, The Extra Pharmacopeoia, 30th ed, p534) 6-Propyl-2-Thiouracil,6 Propyl 2 Thiouracil
D003879 Dermatologic Agents Drugs used to treat or prevent skin disorders or for the routine care of skin. Agent, Dermatologic,Agent, Dermatological,Agents, Dermatologic,Dermatologic Agent,Dermatological Agents,Agents, Dermatological,Dermatological Agent
D004359 Drug Therapy, Combination Therapy with two or more separate preparations given for a combined effect. Combination Chemotherapy,Polychemotherapy,Chemotherapy, Combination,Combination Drug Therapy,Drug Polytherapy,Therapy, Combination Drug,Chemotherapies, Combination,Combination Chemotherapies,Combination Drug Therapies,Drug Polytherapies,Drug Therapies, Combination,Polychemotherapies,Polytherapies, Drug,Polytherapy, Drug,Therapies, Combination Drug
D005260 Female Females
D005938 Glucocorticoids A group of CORTICOSTEROIDS that affect carbohydrate metabolism (GLUCONEOGENESIS, liver glycogen deposition, elevation of BLOOD SUGAR), inhibit ADRENOCORTICOTROPIC HORMONE secretion, and possess pronounced anti-inflammatory activity. They also play a role in fat and protein metabolism, maintenance of arterial blood pressure, alteration of the connective tissue response to injury, reduction in the number of circulating lymphocytes, and functioning of the central nervous system. Glucocorticoid,Glucocorticoid Effect,Glucorticoid Effects,Effect, Glucocorticoid,Effects, Glucorticoid
D006801 Humans Members of the species Homo sapiens. Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D000005 Abdomen That portion of the body that lies between the THORAX and the PELVIS. Abdomens
D000368 Aged A person 65 years of age or older. For a person older than 79 years, AGED, 80 AND OVER is available. Elderly
D013956 Antithyroid Agents Agents that are used to treat hyperthyroidism by reducing the excessive production of thyroid hormones. Antithyroid Agent,Antithyroid Drug,Goitrogen,Goitrogens,Thyroid Antagonists,Antithyroid Drugs,Antithyroid Effect,Antithyroid Effects,Agent, Antithyroid,Agents, Antithyroid,Antagonists, Thyroid,Drug, Antithyroid,Drugs, Antithyroid,Effect, Antithyroid,Effects, Antithyroid

Related Publications

A Coster, and J-L Dargent, and N de Visscher, and P Levecque, and P-P Roquet-Gravy
A case of propylthiouracil-induced pyoderma gangrenosum associated with antineutrophil cytoplasmic antibody.
January 2004, Dermatology (Basel, Switzerland),
A Coster, and J-L Dargent, and N de Visscher, and P Levecque, and P-P Roquet-Gravy
Presence of anti-proteinase 3 antineutrophil cytoplasmic antibodies (anti-PR3 ANCA) as serologic markers in inflammatory bowel disease.
August 2013, Clinical reviews in allergy & immunology,
A Coster, and J-L Dargent, and N de Visscher, and P Levecque, and P-P Roquet-Gravy
The binding of proteinase 3 antineutrophil cytoplasmic antibodies (PR3-ANCA) varies in different ELISAs.
March 2004, Journal of clinical pathology,
A Coster, and J-L Dargent, and N de Visscher, and P Levecque, and P-P Roquet-Gravy
ANCA positive propylthiouracil induced pyoderma gangrenosum.
June 2006, Journal of endocrinological investigation,
A Coster, and J-L Dargent, and N de Visscher, and P Levecque, and P-P Roquet-Gravy
[Neutrophilic dermatosis associated with propylthiouracil-induced p-ANCA (p-antineutrophil cytoplasmic antibodies)].
January 2005, Annales de dermatologie et de venereologie,
A Coster, and J-L Dargent, and N de Visscher, and P Levecque, and P-P Roquet-Gravy
Propylthiouracil-induced antineutrophil cytoplasmic antibody positive vasculitis clinically mimicking pyoderma gangrenosum.
August 2012, The Journal of dermatology,
A Coster, and J-L Dargent, and N de Visscher, and P Levecque, and P-P Roquet-Gravy
The target antigens of antineutrophil cytoplasmic antibodies (ANCA) induced by propylthiouracil.
January 2007, International immunopharmacology,
A Coster, and J-L Dargent, and N de Visscher, and P Levecque, and P-P Roquet-Gravy
[Antineutrophil cytoplasmic antibody (Anca)-associated autoimmune disease induced by propylthiouracil].
February 2007, Arquivos brasileiros de endocrinologia e metabologia,
A Coster, and J-L Dargent, and N de Visscher, and P Levecque, and P-P Roquet-Gravy
Antineutrophil cytoplasmic antibodies (ANCA)-associated crescentic glomerulonephritis and propylthiouracil therapy.
January 1996, Nephron,
A Coster, and J-L Dargent, and N de Visscher, and P Levecque, and P-P Roquet-Gravy
Propylthiouracil induced antineutrophil cytoplasmic antibodies-associated vasculitis.
January 2013, Chinese medical journal,
Copied contents to your clipboard!