BIOMAT Database Logo BIOMAT Database Logo

Monocyte-derived human B-cell growth factor identified as interferon-beta 2 (BSF-2, IL-6). 1988

G Tosato, and K B Seamon, and N D Goldman, and P B Sehgal, and L T May, and G C Washington, and K D Jones, and S E Pike
Division of Biochemistry and Biophysics, Food and Drug Administration, Bethesda, MD 20892.

Soluble products of either Epstein-Barr virus (EBV)-infected B cells or activated monocytes promote the proliferation of EBV-infected B cells and permit their growth at low cell densities. This suggests that growth factors are important for B-cell immortalization by EBV. In this study, a monocyte-derived factor that promotes the growth of EBV-infected b cells was purified and identified as interferon-beta 2 (IFN-beta 2), which is also known as 26-kilodalton protein, B-cell differentiation factor (BSF-2), and interleukin-6 (IL-6). The purified protein has a specific activity of approximately 4 X 10(7) units per milligram of protein in assays of B-cell growth. Thus, IFN-beta 2/BSF-2 is a B-cell growth factor that promotes the proliferation of human B cells infected with EBV.

UI MeSH Term Description Entries
D007118 Immunoassay A technique using antibodies for identifying or quantifying a substance. Usually the substance being studied serves as antigen both in antibody production and in measurement of antibody by the test substance. Immunochromatographic Assay,Assay, Immunochromatographic,Assays, Immunochromatographic,Immunoassays,Immunochromatographic Assays
D007378 Interleukins Soluble factors which stimulate growth-related activities of leukocytes as well as other cell types. They enhance cell proliferation and differentiation, DNA synthesis, secretion of other biologically active molecules and responses to immune and inflammatory stimuli. Interleukin
D009000 Monocytes Large, phagocytic mononuclear leukocytes produced in the vertebrate BONE MARROW and released into the BLOOD; contain a large, oval or somewhat indented nucleus surrounded by voluminous cytoplasm and numerous organelles. Monocyte
D002452 Cell Count The number of CELLS of a specific kind, usually measured per unit volume or area of sample. Cell Density,Cell Number,Cell Counts,Cell Densities,Cell Numbers,Count, Cell,Counts, Cell,Densities, Cell,Density, Cell,Number, Cell,Numbers, Cell
D002455 Cell Division The fission of a CELL. It includes CYTOKINESIS, when the CYTOPLASM of a cell is divided, and CELL NUCLEUS DIVISION. M Phase,Cell Division Phase,Cell Divisions,Division Phase, Cell,Division, Cell,Divisions, Cell,M Phases,Phase, Cell Division,Phase, M,Phases, M
D002478 Cells, Cultured Cells propagated in vitro in special media conducive to their growth. Cultured cells are used to study developmental, morphologic, metabolic, physiologic, and genetic processes, among others. Cultured Cells,Cell, Cultured,Cultured Cell
D004591 Electrophoresis, Polyacrylamide Gel Electrophoresis in which a polyacrylamide gel is used as the diffusion medium. Polyacrylamide Gel Electrophoresis,SDS-PAGE,Sodium Dodecyl Sulfate-PAGE,Gel Electrophoresis, Polyacrylamide,SDS PAGE,Sodium Dodecyl Sulfate PAGE,Sodium Dodecyl Sulfate-PAGEs
D004854 Herpesvirus 4, Human The type species of LYMPHOCRYPTOVIRUS, subfamily GAMMAHERPESVIRINAE, infecting B-cells in humans. It is thought to be the causative agent of INFECTIOUS MONONUCLEOSIS and is strongly associated with oral hairy leukoplakia (LEUKOPLAKIA, HAIRY;), BURKITT LYMPHOMA; and other malignancies. Burkitt Herpesvirus,Burkitt Lymphoma Virus,E-B Virus,EBV,Epstein-Barr Virus,Human Herpesvirus 4,Infectious Mononucleosis Virus,Burkitt's Lymphoma Virus,HHV-4,Herpesvirus 4 (gamma), Human,Burkitts Lymphoma Virus,E B Virus,E-B Viruses,Epstein Barr Virus,Herpesvirus, Burkitt,Infectious Mononucleosis Viruses,Lymphoma Virus, Burkitt,Mononucleosis Virus, Infectious,Mononucleosis Viruses, Infectious
D006801 Humans Members of the species Homo sapiens. Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D001402 B-Lymphocytes Lymphoid cells concerned with humoral immunity. They are short-lived cells resembling bursa-derived lymphocytes of birds in their production of immunoglobulin upon appropriate stimulation. B-Cells, Lymphocyte,B-Lymphocyte,Bursa-Dependent Lymphocytes,B Cells, Lymphocyte,B Lymphocyte,B Lymphocytes,B-Cell, Lymphocyte,Bursa Dependent Lymphocytes,Bursa-Dependent Lymphocyte,Lymphocyte B-Cell,Lymphocyte B-Cells,Lymphocyte, Bursa-Dependent,Lymphocytes, Bursa-Dependent

Related Publications

G Tosato, and K B Seamon, and N D Goldman, and P B Sehgal, and L T May, and G C Washington, and K D Jones, and S E Pike
A monocyte-derived B cell growth factor is IFN-beta 2/BSF-2/IL-6.
January 1989, Annals of the New York Academy of Sciences,
G Tosato, and K B Seamon, and N D Goldman, and P B Sehgal, and L T May, and G C Washington, and K D Jones, and S E Pike
Human beta 2 interferon and B-cell differentiation factor BSF-2 are identical.
February 1987, Science (New York, N.Y.),
G Tosato, and K B Seamon, and N D Goldman, and P B Sehgal, and L T May, and G C Washington, and K D Jones, and S E Pike
Structure and expression of human B cell stimulatory factor-2 (BSF-2/IL-6) gene.
October 1987, The EMBO journal,
G Tosato, and K B Seamon, and N D Goldman, and P B Sehgal, and L T May, and G C Washington, and K D Jones, and S E Pike
IL-2 dependence of the promotion of human B cell differentiation by IL-6 (BSF-2).
January 1990, Journal of immunology (Baltimore, Md. : 1950),
G Tosato, and K B Seamon, and N D Goldman, and P B Sehgal, and L T May, and G C Washington, and K D Jones, and S E Pike
The essential role of B cell stimulatory factor 2 (BSF-2/IL-6) for the terminal differentiation of B cells.
February 1988, The Journal of experimental medicine,
G Tosato, and K B Seamon, and N D Goldman, and P B Sehgal, and L T May, and G C Washington, and K D Jones, and S E Pike
Transcriptional regulation of the interferon-beta 2/B cell differentiation factor BSF-2/hepatocyte-stimulating factor gene in human fibroblasts by other cytokines.
February 1988, Journal of immunology (Baltimore, Md. : 1950),
G Tosato, and K B Seamon, and N D Goldman, and P B Sehgal, and L T May, and G C Washington, and K D Jones, and S E Pike
Establishment of two interleukin 6 (B cell stimulatory factor 2/interferon beta 2)-dependent human bone marrow-derived myeloma cell lines.
January 1989, The Journal of experimental medicine,
G Tosato, and K B Seamon, and N D Goldman, and P B Sehgal, and L T May, and G C Washington, and K D Jones, and S E Pike
Stimulation of EBV-activated human B cells by monocytes and monocyte products. Role of IFN-beta 2/B cell stimulatory factor 2/IL-6.
June 1988, Journal of immunology (Baltimore, Md. : 1950),
G Tosato, and K B Seamon, and N D Goldman, and P B Sehgal, and L T May, and G C Washington, and K D Jones, and S E Pike
Regulation of BSF-2/IL-6 production by human mononuclear cells. Macrophage-dependent synthesis of BSF-2/IL-6 by T cells.
September 1988, Journal of immunology (Baltimore, Md. : 1950),
G Tosato, and K B Seamon, and N D Goldman, and P B Sehgal, and L T May, and G C Washington, and K D Jones, and S E Pike
Interferon-beta 2 (BSF-2) mRNA is expressed in human monocytes.
August 1988, Journal of interferon research,
Copied contents to your clipboard!