OBJECTIVE to assess efficacy of a fixed combination of perindopril arginine and amlodipine besylate in the treatment of hypertensive patients with chronic heart failure (CHF) and signs of chronic kidney disease (CKD). METHODS Persons with CKD (n=53, age 64.5+/-8.2years) were selected from 118 patients with grade 2-3 essential hypertension with CHF. Presence of CKD was confirmed by elevated blood levels of cystatin C and lowered glomerular filtration rate (GFR). Used doses of fixed perindopril/amlodipine combination were 5/5, 5/10, 10/10mg. Efficacy was assessed after 2 months of therapy on the basis of results of the examination which included clinical blood pressure (BP).