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Thirty-five patients received 42 liver homografts between February 1984 and August 1985. One or more infections developed in 23 patients (66%) some time after transplantation. An average of 2.5 infections per infected patient occurred. Of 37 bacterial infections, two thirds were either bacteremias or localized intra-abdominal infections. The median onset was 29 days after operation. Thirteen viral infections were identified, with a median onset of 18 days after operation. Nine fungal infections, six disseminated and three localized, were identified, with a median onset of nine days after operation. Infection was the primary cause of death in five (14%) of 35 patients. Fatal infections were evenly distributed among bacterial (two), fungal (three), and viral (two) pathogens. Despite advances in surgical techniques and the use of cyclosporine, infection after orthotopic liver transplantation is a serious problem. Certain patients can be identified as high risks for infection and require an aggressive diagnostic workup followed by early institution of antimicrobial therapy.
J O Colonna, and
D J Winston, and
J E Brill, and
L I Goldstein, and
M P Hoff, and
J R Hiatt, and
W Quinones-Baldrich, and
K P Ramming, and
R W Busuttil
January 1994,
Annales de radiologie,
J O Colonna, and
D J Winston, and
J E Brill, and
L I Goldstein, and
M P Hoff, and
J R Hiatt, and
W Quinones-Baldrich, and
K P Ramming, and
R W Busuttil
March 1997,
Hong Kong medical journal = Xianggang yi xue za zhi,
J O Colonna, and
D J Winston, and
J E Brill, and
L I Goldstein, and
M P Hoff, and
J R Hiatt, and
W Quinones-Baldrich, and
K P Ramming, and
R W Busuttil
November 2015,
Gastroenterology & hepatology,
J O Colonna, and
D J Winston, and
J E Brill, and
L I Goldstein, and
M P Hoff, and
J R Hiatt, and
W Quinones-Baldrich, and
K P Ramming, and
R W Busuttil
February 2012,
Seminars in respiratory and critical care medicine,
J O Colonna, and
D J Winston, and
J E Brill, and
L I Goldstein, and
M P Hoff, and
J R Hiatt, and
W Quinones-Baldrich, and
K P Ramming, and
R W Busuttil
August 1991,
Journal of pediatric surgery,
J O Colonna, and
D J Winston, and
J E Brill, and
L I Goldstein, and
M P Hoff, and
J R Hiatt, and
W Quinones-Baldrich, and
K P Ramming, and
R W Busuttil
February 2010,
Pediatric transplantation,
J O Colonna, and
D J Winston, and
J E Brill, and
L I Goldstein, and
M P Hoff, and
J R Hiatt, and
W Quinones-Baldrich, and
K P Ramming, and
R W Busuttil
April 1994,
Journal of pediatric surgery,
J O Colonna, and
D J Winston, and
J E Brill, and
L I Goldstein, and
M P Hoff, and
J R Hiatt, and
W Quinones-Baldrich, and
K P Ramming, and
R W Busuttil
January 1993,
Current clinical topics in infectious diseases,
J O Colonna, and
D J Winston, and
J E Brill, and
L I Goldstein, and
M P Hoff, and
J R Hiatt, and
W Quinones-Baldrich, and
K P Ramming, and
R W Busuttil
May 1995,
Seminars in liver disease,
J O Colonna, and
D J Winston, and
J E Brill, and
L I Goldstein, and
M P Hoff, and
J R Hiatt, and
W Quinones-Baldrich, and
K P Ramming, and
R W Busuttil
November 1997,
Liver transplantation and surgery : official publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society,
