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Osteoarthritis is characterized by a loss of articular cartilage due at least in part to the action of degradative enzymes secreted by chondrocytes. We have investigated the effect of type II collagen from cartilage and interleukin 1 on collagenase production in cultures of rabbit articular chondrocytes. Interleukin 1 alone stimulated the chondrocytes to secrete collagenase but this response was increased as much as fivefold by the addition of rabbit type II collagen. Bovine type II and chick type I collagens were also stimulatory. The native form of the collagens was not required since denatured collagens and purified chick type II alpha chains were effective. The observed effects of collagens and interleukin 1 may contribute to the progressive nature of osteoarthritis.
R A Kandel, and
C A Dinarello, and
C Biswas
March 1990,
Biochimica et biophysica acta,
R A Kandel, and
C A Dinarello, and
C Biswas
December 1990,
FEBS letters,
R A Kandel, and
C A Dinarello, and
C Biswas
December 1984,
Collagen and related research,
R A Kandel, and
C A Dinarello, and
C Biswas
November 1990,
Arthritis and rheumatism,
R A Kandel, and
C A Dinarello, and
C Biswas
June 1989,
Agents and actions,
R A Kandel, and
C A Dinarello, and
C Biswas
January 2002,
Arthritis research,
R A Kandel, and
C A Dinarello, and
C Biswas
February 1983,
The Journal of experimental medicine,
R A Kandel, and
C A Dinarello, and
C Biswas
July 1988,
Archives of biochemistry and biophysics,
R A Kandel, and
C A Dinarello, and
C Biswas
September 1994,
Annals of the New York Academy of Sciences,
R A Kandel, and
C A Dinarello, and
C Biswas
June 1984,
European journal of immunology,
