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Chromosomal mosaicism is a relatively common finding in human IVF embryos. However, the association between mosaicism in trophoectoderm and inner mass cells, the mechanisms involved, and its effects on implantation are far from established. We retrospectively reanalyzed array-CGH results from 1,362 trophoectoderm biopsies. We detected chromosomal mosaicism in 183 blastocysts (13.4%). A decrease in the clinical pregnancy rate when we compared the cycles where only mosaic embryos were transferred (26.9%) vs. euploid embryos were transferred (40.2%) was not statistically different (p = 0.127). Also a tendency to increase the biochemical miscarriage was reported (21.2% mosaic group vs. 12.3% euploid group; p=0.102). Our data suggests that the transfer of some mosaic embryos achieve full term pregnancies. Additional studies are needed to clarify how embryo mosaicism affects the outcomes of the IVF cycles.
Belén Lledó, and
Ruth Morales, and
Jose Antonio Ortiz, and
Helena Blanca, and
Jorge Ten, and
Joaquín Llácer, and
Rafael Bernabeu
January 2023,
Frontiers in cell and developmental biology,
Belén Lledó, and
Ruth Morales, and
Jose Antonio Ortiz, and
Helena Blanca, and
Jorge Ten, and
Joaquín Llácer, and
Rafael Bernabeu
January 2020,
Gynecologic and obstetric investigation,
Belén Lledó, and
Ruth Morales, and
Jose Antonio Ortiz, and
Helena Blanca, and
Jorge Ten, and
Joaquín Llácer, and
Rafael Bernabeu
August 2020,
Nature communications,
Belén Lledó, and
Ruth Morales, and
Jose Antonio Ortiz, and
Helena Blanca, and
Jorge Ten, and
Joaquín Llácer, and
Rafael Bernabeu
March 2002,
The EMBO journal,
Belén Lledó, and
Ruth Morales, and
Jose Antonio Ortiz, and
Helena Blanca, and
Jorge Ten, and
Joaquín Llácer, and
Rafael Bernabeu
October 2021,
Journal of obstetrics and gynaecology : the journal of the Institute of Obstetrics and Gynaecology,
Belén Lledó, and
Ruth Morales, and
Jose Antonio Ortiz, and
Helena Blanca, and
Jorge Ten, and
Joaquín Llácer, and
Rafael Bernabeu
June 2023,
The journal of obstetrics and gynaecology research,
Belén Lledó, and
Ruth Morales, and
Jose Antonio Ortiz, and
Helena Blanca, and
Jorge Ten, and
Joaquín Llácer, and
Rafael Bernabeu
January 2015,
The Journal of reproduction and development,
Belén Lledó, and
Ruth Morales, and
Jose Antonio Ortiz, and
Helena Blanca, and
Jorge Ten, and
Joaquín Llácer, and
Rafael Bernabeu
August 2014,
Reproductive biomedicine online,
Belén Lledó, and
Ruth Morales, and
Jose Antonio Ortiz, and
Helena Blanca, and
Jorge Ten, and
Joaquín Llácer, and
Rafael Bernabeu
July 2021,
Fertility and sterility,
Belén Lledó, and
Ruth Morales, and
Jose Antonio Ortiz, and
Helena Blanca, and
Jorge Ten, and
Joaquín Llácer, and
Rafael Bernabeu
May 2014,
Fertility and sterility,
