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Inhibition of superoxide anion production in guinea pig polymorphonuclear leukocytes by a seleno-organic compound, ebselen. 1987
S Ichikawa, and
K Omura, and
T Katayama, and
N Okamura, and
T Ohtsuka, and
S Ishibashi, and
H Masayasu
Department of Physiological Chemistry, Hiroshima University School of Medicine, Japan.
Production of superoxide anion (O2-) induced by tetradecanoyl phorbol acetate (TPA) in intact guinea pig polymorphonuclear leukocytes (PMNL) was markedly inhibited by a seleno-organic compound, 2-phenyl-1,2-benzisoselenazol-3(2H)-one (Ebselen), with glutathione peroxidase-like activity. The compound almost completely inhibited O2- production by a particulate fraction prepared from TPA-treated PMNL at a concentration as low as 250 nM.
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