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Chemotherapy-induced cardiomyopathy (CCMP) is a complication of chemotherapy treatment occurring in 9% of patients treated with the use of anthracyclines. Currently, risk stratification is based on clinical risk factors that do not adequately account for variable individual susceptibility. This suggests the presence of other determinants. In this case series, we describe 2 women with breast cancer who developed severe heart failure within months after chemotherapy. Genetic screening revealed truncating frameshift mutations in TTN, encoding the myofilament titin, in both women. To our knowledge, this is the 1st report of an association between truncating TTN variants and CCMP. Because truncations in TTN are the most common cause of familial and sporadic dilated cardiomyopathy, further research is needed to establish their prevalence in patients presenting with CCMP.
M Linschoten, and
A J Teske, and
A F Baas, and
A Vink, and
D Dooijes, and
H F Baars, and
F W Asselbergs
October 2021,
Circulation. Genomic and precision medicine,
M Linschoten, and
A J Teske, and
A F Baas, and
A Vink, and
D Dooijes, and
H F Baars, and
F W Asselbergs
January 2024,
medRxiv : the preprint server for health sciences,
M Linschoten, and
A J Teske, and
A F Baas, and
A Vink, and
D Dooijes, and
H F Baars, and
F W Asselbergs
January 2017,
PloS one,
M Linschoten, and
A J Teske, and
A F Baas, and
A Vink, and
D Dooijes, and
H F Baars, and
F W Asselbergs
October 2013,
Neurology,
M Linschoten, and
A J Teske, and
A F Baas, and
A Vink, and
D Dooijes, and
H F Baars, and
F W Asselbergs
June 2017,
Biophysical reviews,
M Linschoten, and
A J Teske, and
A F Baas, and
A Vink, and
D Dooijes, and
H F Baars, and
F W Asselbergs
May 2017,
Journal of the American College of Cardiology,
M Linschoten, and
A J Teske, and
A F Baas, and
A Vink, and
D Dooijes, and
H F Baars, and
F W Asselbergs
July 2020,
Revista espanola de cardiologia (English ed.),
M Linschoten, and
A J Teske, and
A F Baas, and
A Vink, and
D Dooijes, and
H F Baars, and
F W Asselbergs
February 2023,
Circulation. Genomic and precision medicine,
M Linschoten, and
A J Teske, and
A F Baas, and
A Vink, and
D Dooijes, and
H F Baars, and
F W Asselbergs
October 2020,
Circulation. Heart failure,
M Linschoten, and
A J Teske, and
A F Baas, and
A Vink, and
D Dooijes, and
H F Baars, and
F W Asselbergs
July 2016,
Clinical genetics,
