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In isolated perfused rat liver leukotriene C4 and D4 but not B4 and E4 enhanced glucose and lactate output and lowered perfusion flow similar to the thromboxane A2 analogue U46619, extracellular ATP and prostaglandin F2 alpha. The kinetics of the metabolic changes caused by leukotriene C4 and D4 resembled those effected by U46619 and ATP but not those elicited by prostaglandin F2 alpha; the kinetics of the hemodynamic changes were similar only to those caused by U46619. The results show that leukotrienes could be important modulators of hepatic metabolism and hemodynamics and point to a complex intra-organ cell-cell communication between non-parenchymal and parenchymal cells.
M Iwai, and
K Jungermann
January 1989,
FEBS letters,
M Iwai, and
K Jungermann
March 1991,
European journal of biochemistry,
M Iwai, and
K Jungermann
March 1992,
Hepatology (Baltimore, Md.),
M Iwai, and
K Jungermann
November 1990,
Scandinavian journal of clinical and laboratory investigation,
M Iwai, and
K Jungermann
June 1982,
Biochimica et biophysica acta,
M Iwai, and
K Jungermann
September 1991,
Hepatology (Baltimore, Md.),
M Iwai, and
K Jungermann
January 1995,
Peptides,
M Iwai, and
K Jungermann
January 1966,
Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.),
M Iwai, and
K Jungermann
July 2002,
American journal of physiology. Heart and circulatory physiology,
M Iwai, and
K Jungermann
January 1989,
Experimental and clinical endocrinology,
