-transparent.png){kind=logo}
The preincubation of isolated washed human platelets with lipopolysaccharide toxin (LPS) from Salmonella typhimurium (10 min, 37 degrees) speeds up the thrombin-induced aggregation. Besides, LPS-pretreatment was shown to alter the turnover of polyphosphoinositides stimulated by thrombin and significantly elevated concentrations of diacylglycerol and thromboxane B2 in comparison with control platelets. However, LPS does not influence on the lipid fluidizing effect of thrombin action as testifies by ESR spectroscopy with doxyl-stearic acids as spin-probes. An LPS pretreatment of platelets that induces no aggregation by itself is proposed might transform cells into a state of hidden activation" associated with the accumulation of such products as diacylglycerol and precursors of thromboxane B2. Addition of thrombin to such "preactivated" platelets could cause a more effective aggregation.
A V Viktorov, and
E Kh Dank, and
V A Kuznetsov, and
V G Ter-Simonian, and
V A Iurkiv
November 1993,
Biulleten' eksperimental'noi biologii i meditsiny,
A V Viktorov, and
E Kh Dank, and
V A Kuznetsov, and
V G Ter-Simonian, and
V A Iurkiv
February 2010,
Human immunology,
A V Viktorov, and
E Kh Dank, and
V A Kuznetsov, and
V G Ter-Simonian, and
V A Iurkiv
January 1981,
Bilten za hematologiju i transfuziju,
A V Viktorov, and
E Kh Dank, and
V A Kuznetsov, and
V G Ter-Simonian, and
V A Iurkiv
January 2012,
Journal of reproductive immunology,
A V Viktorov, and
E Kh Dank, and
V A Kuznetsov, and
V G Ter-Simonian, and
V A Iurkiv
January 2014,
PloS one,
A V Viktorov, and
E Kh Dank, and
V A Kuznetsov, and
V G Ter-Simonian, and
V A Iurkiv
November 1998,
Journal of leukocyte biology,
A V Viktorov, and
E Kh Dank, and
V A Kuznetsov, and
V G Ter-Simonian, and
V A Iurkiv
September 2015,
The Journal of the Acoustical Society of America,
A V Viktorov, and
E Kh Dank, and
V A Kuznetsov, and
V G Ter-Simonian, and
V A Iurkiv
January 1980,
L'Ateneo parmense. Acta bio-medica : organo della Societa di medicina e scienze naturali di Parma,
A V Viktorov, and
E Kh Dank, and
V A Kuznetsov, and
V G Ter-Simonian, and
V A Iurkiv
January 1984,
Voprosy meditsinskoi khimii,
A V Viktorov, and
E Kh Dank, and
V A Kuznetsov, and
V G Ter-Simonian, and
V A Iurkiv
June 2006,
Oral microbiology and immunology,
