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This review analyzes recent data on mechanisms of cerebral hypoxia and the protective methods of hypoxic and ischemic postconditioning, as well as their interrelationship with the key mechanisms responsible for neuroprotection and neuroplasticity. Upregulation of expression of antiapoptotic factors and neurotrophins and modulation of activity of several protein kinases and transcription factors such as hypoxia-inducible factor-1 (HIF-1) are considered as the most important aspects in the neuroprotective potential of postconditioning. The presented information indicates substantial transformative promise of the noninvasive techniques of hypoxic postconditioning as well as significant similarity between the adaptive pathways activated by various postconditioning methods, which are far from being fully understood.
O V Vetrovoy, and
E A Rybnikova, and
M O Samoilov
January 2016,
Uspekhi fiziologicheskikh nauk,
O V Vetrovoy, and
E A Rybnikova, and
M O Samoilov
March 2015,
The International journal of neuroscience,
O V Vetrovoy, and
E A Rybnikova, and
M O Samoilov
August 2023,
Neuroscience,
O V Vetrovoy, and
E A Rybnikova, and
M O Samoilov
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Brain pathology (Zurich, Switzerland),
O V Vetrovoy, and
E A Rybnikova, and
M O Samoilov
June 2011,
Zhonghua yi xue za zhi,
O V Vetrovoy, and
E A Rybnikova, and
M O Samoilov
July 2014,
Molecular and cellular biochemistry,
O V Vetrovoy, and
E A Rybnikova, and
M O Samoilov
October 2009,
Stroke,
O V Vetrovoy, and
E A Rybnikova, and
M O Samoilov
January 1995,
Pharmacology & therapeutics,
O V Vetrovoy, and
E A Rybnikova, and
M O Samoilov
May 2015,
World journal of pediatrics : WJP,
O V Vetrovoy, and
E A Rybnikova, and
M O Samoilov
December 2003,
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